弥散加权成像与弥散张量成像在儿童脑积水中的应用价值
发布时间：2018-08-31 15:39
【摘要】：目的 利用弥散加权成像(diffusion weight imaging, DWI)及弥散张量成像(diffusion-tensor imaging, DTI)序列对儿童脑积水患儿双侧脑室周围脑白质及胼胝体压部、膝部内水分子弥散运动情况和各向异性进行研究,探讨DWI与DTI对儿童梗阻性脑积水的应用价值。 材料与方法 选取20例无神经系统及运动障碍疾病的正常儿童志愿者作为对照组,33例经手术治疗的由导水管狭窄或肿瘤造成的明显梗阻性脑积水患儿为实验组。正常对照组及HIE病例组均使用GE Signa EXCITE HD3.0T超导磁共振扫描仪,采用头线圈。使用MRI常规序列(横断位T1WI、T2WI、FLAIR、矢状位T2WI)及DWI序列、DTI序列扫描,在ADW4.0工作站上利用Functiontool软件分别对病例进行DWI及DTI后处理,重建出ADC图、MD图、FA图、RA图、VR图、AI图及纤维束图。记录相关所测定参数并应用SPSS13.0软件进行统计分析,将两组数据进行正态检验并进行两样本t检验,P0.05被认为差异有统计意义。结果 20例儿童志愿者及33例脑积水患儿分别测量双侧侧脑室周围脑白质、胼胝体膝部及压部区域的DWI及DTI所测得的参数ADC、MD、FA、RA、VR及AI。利用SPSS13.0统计学软件进行统计学分析,所有数据经过正态分布检验,符合正态分布,经过独立样本t检验。ADC图中胼胝体膝部两组ADC值差异具有统计学意义,p0.05。胼胝体压部RA值有统计学差异,p0.05，胼胝体膝部两组间所有测得DTI各参数值均无统计学差异,双侧侧脑室周围脑白质所测得MD、FA、VR、AI值均有统计学意义,p0.05。 结论 1、DWI和DTI可以有效地检测出儿童脑积水中的胼胝体膝部ADC值、压部RA值以及双侧侧脑室周围脑白质MD、FA、VR、AI值的异常改变。 2、DWI和DTI具有无创、安全可靠的特点,是目前诊断儿童脑积水比较理想的MR检查方法。 3、常规MRI、DWI和DTI联合应用,可以全面且准确地评价儿童脑积水,为脑积水的诊断及鉴别诊断提供有力依据。
[Abstract]:Objective to study the diffusion motion and anisotropy of water molecules in bilateral periventricular white matter and corpus callosum in children with hydrocephalus by using diffusion weighted imaging (diffusion weight imaging, DWI) and diffusion-weighted Zhang Liang imaging (diffusion-tensor imaging, DTI). To investigate the value of DWI and DTI in children with obstructive hydrocephalus. Materials and methods 20 normal children without neurological and motor disorders were selected as control group. 33 children with obstructive hydrocephalus caused by aqueduct stenosis or tumor were selected as experimental group. GE Signa EXCITE HD3.0T superconducting magnetic resonance scanner and head coil were used in normal control group and HIE case group. Using MRI routine sequence (T1WIT2WIFLAIRT, sagittal T2WI) and DWI sequence, DWI and DTI postprocessing were performed on ADW4.0 workstation respectively, and the AI and fibrobundle images of RA / RA / RA were reconstructed by Functiontool software on ADW4.0 workstation. The correlation parameters were recorded and analyzed by SPSS13.0 software. The two groups of data were tested by normal and t-test of two samples. P0.05 was considered to have statistical significance. Results the parameters of ADC,MD,FA,RA,VR and AI. were measured by DWI and DTI in bilateral periventricular white matter, genu of corpus callosum and splenium in 20 children volunteers and 33 children with hydrocephalus. All the data were tested by normal distribution and accorded with normal distribution. The difference of ADC value between the two groups in the genu of corpus callosum was statistically significant after t-test of independent sample. The RA value of corpus callosum was significantly different between the two groups (p0.05). There was no significant difference in all the parameters of DTI between the two groups. The MD,FA,VR,AI values of bilateral periventricular white matter were statistically significant (P 0.05). Conclusion 1DWI and DTI can effectively detect the abnormal changes of ADC value in the genu of corpus callosum, RA value of the superior part of the corpus callosum and the MD,FA,VR,AI value of the white matter around the ventricle in children with hydrocephalus. 2DWI and DTI are noninvasive, safe and reliable. It is an ideal MR method for the diagnosis of hydrocephalus in children at present. (3) the combination of conventional MRI,DWI and DTI can evaluate hydrocephalus in children comprehensively and accurately, and provide a powerful basis for the diagnosis and differential diagnosis of hydrocephalus.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R445.2;R742.7
本文编号：2215432
[Abstract]:Objective to study the diffusion motion and anisotropy of water molecules in bilateral periventricular white matter and corpus callosum in children with hydrocephalus by using diffusion weighted imaging (diffusion weight imaging, DWI) and diffusion-weighted Zhang Liang imaging (diffusion-tensor imaging, DTI). To investigate the value of DWI and DTI in children with obstructive hydrocephalus. Materials and methods 20 normal children without neurological and motor disorders were selected as control group. 33 children with obstructive hydrocephalus caused by aqueduct stenosis or tumor were selected as experimental group. GE Signa EXCITE HD3.0T superconducting magnetic resonance scanner and head coil were used in normal control group and HIE case group. Using MRI routine sequence (T1WIT2WIFLAIRT, sagittal T2WI) and DWI sequence, DWI and DTI postprocessing were performed on ADW4.0 workstation respectively, and the AI and fibrobundle images of RA / RA / RA were reconstructed by Functiontool software on ADW4.0 workstation. The correlation parameters were recorded and analyzed by SPSS13.0 software. The two groups of data were tested by normal and t-test of two samples. P0.05 was considered to have statistical significance. Results the parameters of ADC,MD,FA,RA,VR and AI. were measured by DWI and DTI in bilateral periventricular white matter, genu of corpus callosum and splenium in 20 children volunteers and 33 children with hydrocephalus. All the data were tested by normal distribution and accorded with normal distribution. The difference of ADC value between the two groups in the genu of corpus callosum was statistically significant after t-test of independent sample. The RA value of corpus callosum was significantly different between the two groups (p0.05). There was no significant difference in all the parameters of DTI between the two groups. The MD,FA,VR,AI values of bilateral periventricular white matter were statistically significant (P 0.05). Conclusion 1DWI and DTI can effectively detect the abnormal changes of ADC value in the genu of corpus callosum, RA value of the superior part of the corpus callosum and the MD,FA,VR,AI value of the white matter around the ventricle in children with hydrocephalus. 2DWI and DTI are noninvasive, safe and reliable. It is an ideal MR method for the diagnosis of hydrocephalus in children at present. (3) the combination of conventional MRI,DWI and DTI can evaluate hydrocephalus in children comprehensively and accurately, and provide a powerful basis for the diagnosis and differential diagnosis of hydrocephalus.
【学位授予单位】：山东大学
【学位级别】：硕士
【学位授予年份】：2013
【分类号】：R445.2;R742.7
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