儿童噬血细胞综合征1例报告并文献复习

发布时间：2018-09-03 08:34

【摘要】：目的：提高年轻医师对噬血细胞综合征的认识及积累诊治经验。方法：报告一例儿童噬血细胞综合征的临床表现、实验室检查、诊治经过及文献复习。设计：病例报告。病例：一例8岁男性患儿,病程中主要表现为发热、全身瘀斑、肝脾肿大、全血细胞减少,肝功能严重损害,综合患儿实验室检查符合噬血细胞综合征诊断标准。干预：开始时经积极抗感染、血浆及红细胞、静脉用丙种球蛋白、糖皮质激素及对症等治疗,病情好转。但上呼吸道感染后,临床症状、体征再次加重,在上述治疗基础上加用依托泊苷化疗后病情得到很快控制,症状、体征明显改善,实验室各项指标基本恢复正常。但经再次感染后,临床症状较前次加重,继续原方案治疗。结果：治疗效果欠佳,家长放弃继续在我院治疗,自动出院。结论：噬血细胞综合征是一类少见的恶性血液性疾病,病情进展快,死亡率高,早期控制基础疾病的同时,积极免疫—化疗的治疗是较为恰当的治疗。
[Abstract]:Objective: to improve the knowledge of young doctors on hemophagocytic syndrome and accumulate experience in diagnosis and treatment. Methods: a case of hemophagocytic syndrome in children was reported. Design: case report. Case: an 8-year-old male patient with fever, systemic ecchymosis, hepatosplenomegaly, decreased whole blood cells and severe damage of liver function was found in the course of the disease. The laboratory examination of the patient was in accordance with the diagnostic criteria of hemophagocytic syndrome. Interventions: after active anti-infection, plasma and red blood cell, intravenous gamma globulin, glucocorticoid and symptomatic treatment, etc. But after the upper respiratory tract infection, the clinical symptoms and signs became more serious again. The symptoms and signs were obviously improved and the laboratory indexes were basically restored to normal after the treatment with etoposide chemotherapy. But after re-infection, the clinical symptoms were more severe than the previous, continue the original treatment. Results: the effect of treatment was poor, parents gave up to continue treatment in our hospital, automatic discharge. Conclusion: hemophagocytic syndrome is a rare malignant hematologic disease with rapid progression and high mortality.
【学位授予单位】：兰州大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R725.5

【参考文献】