儿童肾病综合征肾组织病理免疫荧光分型和病理类型与激素疗效关系
发布时间：2018-09-05 14:45
【摘要】：目的分析肾组织病理免疫荧光分型和病理类型及激素疗效的相关性。方法回顾性分析1990年1月至2015年12月临床诊断为肾病综合征(NS)并行肾穿刺活检患儿的肾组织病理及临床随访资料。结果 252例NS患儿的年龄分布为0.8~15岁,男女比例为3.94:1。肾组织病理免疫荧光类型分布为:IgA为主型13例(5.16%),Ig M为主型78例(30.95%),补体为主型19例(7.54%),IgG+A+M型17例(6.75%),Ig G+A+M+补体型22例(8.73%),IgA+补体型2例(0.79%),Ig M+补体型55例(21.83%),无免疫复合物型46例(18.25%);肾组织病理类型中轻微病变(MCNS)157例(62.3%),系膜增生性肾小球肾炎(Ms PGN)35例(13.89%),局灶节段肾小球硬化(FSGS)60例(23.81%)。使用激素4周内完全缓解167例(77.31%),部分缓解31例(14.35%),激素无效18例(8.33%)。8种不同病理免疫荧光分型患儿的病理类型分布差异有统计学意义(χ~2=31.308,P=0.001),但激素疗效差异无统计学意义(P0.05)。结论不同病理免疫荧光分型的病理类型分布有差异,提示免疫荧光沉积情况对NS临床评估可能有一定价值。
[Abstract]:Objective to analyze the correlation between renal histopathological immunofluorescence classification, pathological type and hormone therapeutic effect. Methods from January 1990 to December 2015, renal histopathology and clinical follow-up data of children with nephrotic syndrome (NS) and renal biopsy were retrospectively analyzed. Results the age distribution of 252 cases with NS was 0.815 years old, the ratio of male to female was 3.94: 1. There were 13 cases (5.16%) of IgA predominant type in renal tissues, 78 cases (30.95%) of IgM predominant type, 19 cases (7.54%) of complement predominant type, 17 cases (6.75%) of Ig G A M M type, 22 cases (8.73%) of Ig G A M type, 2 cases (0.79%) of Ig M complement type, 55 cases (21.83%) of Ig M complement type. There were 46 cases (18.25%) of type A, 157 cases (62.3%) of (MCNS), 35 cases (13.89%) of Mesangial proliferative glomerulonephritis and 60 cases (23.81%) of (FSGS) of focal segmental glomerulosclerosis. Within 4 weeks, 167 cases (77.31%) had complete remission, 31 cases (14.35%) had partial remission, 18 cases (8.33%) had no hormone failure, and there were significant differences in the distribution of pathological types of 8 different types of pathological immunofluorescence (蠂 ~ (2 +) ~ (31.308) P ~ (0. 001), but there was no significant difference in the effect of hormone (P0.05). Conclusion there are differences in the distribution of pathological types among different pathological immunofluorescence types, suggesting that immunofluorescence deposition may be of some value in the clinical evaluation of NS.
【作者单位】： 上海交通大学医学院附属新华医院小儿肾脏内科;
【分类号】：R726.9
，
本文编号：2224597
[Abstract]:Objective to analyze the correlation between renal histopathological immunofluorescence classification, pathological type and hormone therapeutic effect. Methods from January 1990 to December 2015, renal histopathology and clinical follow-up data of children with nephrotic syndrome (NS) and renal biopsy were retrospectively analyzed. Results the age distribution of 252 cases with NS was 0.815 years old, the ratio of male to female was 3.94: 1. There were 13 cases (5.16%) of IgA predominant type in renal tissues, 78 cases (30.95%) of IgM predominant type, 19 cases (7.54%) of complement predominant type, 17 cases (6.75%) of Ig G A M M type, 22 cases (8.73%) of Ig G A M type, 2 cases (0.79%) of Ig M complement type, 55 cases (21.83%) of Ig M complement type. There were 46 cases (18.25%) of type A, 157 cases (62.3%) of (MCNS), 35 cases (13.89%) of Mesangial proliferative glomerulonephritis and 60 cases (23.81%) of (FSGS) of focal segmental glomerulosclerosis. Within 4 weeks, 167 cases (77.31%) had complete remission, 31 cases (14.35%) had partial remission, 18 cases (8.33%) had no hormone failure, and there were significant differences in the distribution of pathological types of 8 different types of pathological immunofluorescence (蠂 ~ (2 +) ~ (31.308) P ~ (0. 001), but there was no significant difference in the effect of hormone (P0.05). Conclusion there are differences in the distribution of pathological types among different pathological immunofluorescence types, suggesting that immunofluorescence deposition may be of some value in the clinical evaluation of NS.
【作者单位】： 上海交通大学医学院附属新华医院小儿肾脏内科;
【分类号】：R726.9
，
本文编号：2224597
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2224597.html
最近更新
教材专著
