不同胎龄及出生体质量早产儿早期神经发育的纵向研究

发布时间：2018-09-05 15:58

【摘要】：目的探讨早产儿早期神经发育趋势。方法随访早产儿及足月儿于12、24月龄时(早产儿为校正年龄),以Bayley婴幼儿发育量表评估的智力发育指数(MDI)及运动发育指数(PDI)的差异。结果 12月龄时,出生胎龄32周、32~33~(+6)周、34~36~(+6)周早产儿各组与足月儿组之间按校正年龄(CA)的PDI得分差异无统计学意义(P=0.820);足月儿和出生胎龄34~36~(+6)周组按实际年龄(UCA)的MDI和PDI得分均高于32周和32~33~(+6)周组,足月儿组的PDI得分高于34~36~(+6)周组,差异均有统计学意义(P0.05)。不同出生体质量早产儿与足月儿组之间按CA的PDI得分比较差异无统计学意义(P=0.166),≥2 500 g早产儿及足月儿组按UCA的MDI和PDI得分高于出生体质量1 500 g、1 500~1 999 g及2 000~2 499 g早产儿组,差异均有统计学意义(P0.05)。24月龄时,按UCA的MDI得分足月儿组高于出生胎龄32周、32~33~(+6)周、34~36~(+6)周早产儿组,也高于出生体质量1 500 g、1 500~1 999 g及2 000~2 499 g早产儿组,差异均有统计学意义(P0.05)。1 500g早产儿组按UCA的MDI曲线呈下降趋势,而按UCA的PDI曲线呈明显上升趋势。结论早产儿CA12月龄、24月龄时神经发育基本达同龄足月儿水平。
[Abstract]:Objective to explore the trend of early nerve development in premature infants. Methods the intellectual development index (MDI) and motor development index (PDI) of preterm infants and term infants were evaluated by Bayley Infant Development scale at the age of 12 to 24 months. Results at the age of 12 months, There was no significant difference in PDI scores of corrected age (CA) between preterm infants and term infants at 32 weeks of gestational age (32 weeks) and 32 weeks of gestational age (36 ~ (6) weeks) (P0. 820), and the MDI and PDI scores of (UCA) by age of 34 36 ~ (6) weeks of gestational age group were higher than those of normal age group (P < 0. 820). 32 weeks and 32 ~ (6) weeks, The PDI score of term group was higher than that of 34 ~ 36 ~ (6) weeks group, the difference was statistically significant (P0.05). There was no significant difference in PDI score according to CA between preterm infants with different birth weight and term infants (P0. 166). The MDI and PDI scores of UCA in preterm infants 鈮，

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