维生素D水平与毛细支气管炎的相关研究
发布时间：2018-09-06 18:42
【摘要】：目的：探讨血清维生素D与毛细支气管炎的临床联系。方法按照毛细支气管炎诊断标准,从来新疆医科大学第一附属医院就诊的患儿中选取190例缺乏维生素D的毛细支气管炎患儿,随机分为实验组和对照组,其中实验组91例(男61例,女30例)与对照组99例(男70例,女29例),所有实验组患儿均在入院后进行抗感染治疗,并开始补充维生素D1个月。所有对照组均在入院后进行抗感染治疗,治疗方法同实验组。记录两组患儿临床症状缓解时间及住院天数,并于治疗前检测所有患儿血清25-OHD3、IgA、IgG、CD4+、CD8+、CD4+/CD8+水平,对以上两组研究对象进行追踪随访3个月,满3个月后,复查相关指标并统计两组的复发次数。结果治疗前实验组与对照组患儿血清25-羟维生素D3(25-OHD3)、ALP、IgA、IgG、 CD4+、CD8+、CD4+/CD8+水平相比较,差异均无统计学意义(P0.05)。治疗后,实验组血清IgA、IgG水平均较治疗前高,差异有统计学意义(P0.05),而血清ALP跟治疗前相比,差异无统计学意义(P0.05)；治疗后实验组血清ALP、IgA、IgG, CD4+、CD8+、CD4+/CD8+水平与对照组相比,实验组IgA、IgG、CD4+、CD4+/CD8+水平均较对照组增高,差异有统计学意义(P0.05),而血清ALP、CD8+差异无统计学意义(P0.05)。实验组住院天数及症状缓解天数均较对照组短,差异有统计学意义(P0.05),且出院后复发次数较对照组少,差异有统计学意义(P0.05)。结论维生素D可以通过对机体免疫功能的调节来影响毛细支气管炎的预防及治疗,对毛细支气管炎的预防及治疗发挥着积极作用。
[Abstract]:Objective: to investigate the relationship between serum vitamin D and bronchiolitis. Methods according to the diagnostic criteria of bronchiolitis, 190 children with vitamin D deficiency bronchiolitis were randomly divided into experimental group and control group. There were 91 cases in the experimental group (61 males, 30 females) and 99 cases in the control group (70 males and 29 females). All the children in the experimental group were treated with antiinfective therapy after admission, and vitamin D supplementation was started for 1 month. All the control groups were treated with anti-infection after admission, the treatment method was the same as the experimental group. The clinical symptom remission time and hospitalization days were recorded, and the serum levels of 25-OHD3 IgA- IgA- IgA- CD 4, T 8, CD 8 / CD 8 were measured before treatment. The patients in the two groups were followed up for 3 months, and 3 months later, the patients in the two groups were followed up for 3 months, and the patients in the two groups were followed up for 3 months. To review the relevant indicators and count the number of recurrence in the two groups. Results before treatment, the levels of serum 25-hydroxyvitamin D _ 3 (25-OHD3) IgG, CD4 CD8 ~ + CD4 / CD8 were not significantly different between the experimental group and the control group (P0.05). After treatment, the level of serum IgA,IgG in the experimental group was higher than that before treatment (P0.05), but the serum ALP level was not significantly different from that before treatment (P0.05). After treatment, the serum ALP,IgA,IgG, CD4 CD8 + CD4 / CD8 level of the experimental group was higher than that of the control group. The levels of CD4 / CD8 in the experimental group were significantly higher than those in the control group (P0.05), but there was no significant difference in serum ALP,CD8 (P0.05). The days of hospitalization and symptom relief in the experimental group were shorter than those in the control group, the difference was statistically significant (P0.05), and the number of relapse after discharge was less than that in the control group (P0.05). Conclusion Vitamin D can affect the prevention and treatment of bronchiolitis through the regulation of immune function, and it plays an active role in the prevention and treatment of bronchiolitis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R725.6
本文编号：2227194
[Abstract]:Objective: to investigate the relationship between serum vitamin D and bronchiolitis. Methods according to the diagnostic criteria of bronchiolitis, 190 children with vitamin D deficiency bronchiolitis were randomly divided into experimental group and control group. There were 91 cases in the experimental group (61 males, 30 females) and 99 cases in the control group (70 males and 29 females). All the children in the experimental group were treated with antiinfective therapy after admission, and vitamin D supplementation was started for 1 month. All the control groups were treated with anti-infection after admission, the treatment method was the same as the experimental group. The clinical symptom remission time and hospitalization days were recorded, and the serum levels of 25-OHD3 IgA- IgA- IgA- CD 4, T 8, CD 8 / CD 8 were measured before treatment. The patients in the two groups were followed up for 3 months, and 3 months later, the patients in the two groups were followed up for 3 months, and the patients in the two groups were followed up for 3 months. To review the relevant indicators and count the number of recurrence in the two groups. Results before treatment, the levels of serum 25-hydroxyvitamin D _ 3 (25-OHD3) IgG, CD4 CD8 ~ + CD4 / CD8 were not significantly different between the experimental group and the control group (P0.05). After treatment, the level of serum IgA,IgG in the experimental group was higher than that before treatment (P0.05), but the serum ALP level was not significantly different from that before treatment (P0.05). After treatment, the serum ALP,IgA,IgG, CD4 CD8 + CD4 / CD8 level of the experimental group was higher than that of the control group. The levels of CD4 / CD8 in the experimental group were significantly higher than those in the control group (P0.05), but there was no significant difference in serum ALP,CD8 (P0.05). The days of hospitalization and symptom relief in the experimental group were shorter than those in the control group, the difference was statistically significant (P0.05), and the number of relapse after discharge was less than that in the control group (P0.05). Conclusion Vitamin D can affect the prevention and treatment of bronchiolitis through the regulation of immune function, and it plays an active role in the prevention and treatment of bronchiolitis.
【学位授予单位】：新疆医科大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R725.6
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