联合血降钙素原、脑钠肽、D-二聚体及PCIS评分对评估儿童重症肺炎预后的价值

发布时间：2018-09-11 06:35

【摘要】：目的评价早期联合血降钙素原(PCT)、脑钠肽(BNP)、D-二聚体(DD)以及PCIS评分在评估儿童重症肺炎预后中的价值。方法选取重症肺炎患儿80例作为研究对象,其中男49例、女31例,中位年龄7.5个月(1~156个月),根据患儿病情的最终转归分为治愈组和预后不良组;记录患儿入住儿童重症监护病房(PICU)24 h内的PCIS分值和PCT、BNP、DD数值,对上述指标绘制各自的受试者工作特征曲线(ROC曲线),比较各自的曲线下面积(AUC)。同时联合这四项指标绘制ROC曲线,并与各单独指标的AUC比较,评价联合诊断的优劣。结果入住PICU 24 h内的PCT、BNP、DD水平及PCIS各自的AUC均介于0.7~0.9之间,而联合这四种指标的ROC曲线的AUC为0.932,灵敏度和特异度均有所提高。结论联合PCIS评分、BNP、降钙素原、DD水平可以提高对儿童重症肺炎预后评估的准确率。
[Abstract]:Objective to evaluate the value of early serum calcitonin (PCT), combined with brain natriuretic peptide (BNP) (BNP) D-dimer (DD) and PCIS score in evaluating the prognosis of severe pneumonia in children. Methods A total of 80 children with severe pneumonia were selected, including 49 males and 31 females with a median age of 7.5 months (1 ~ 156 months). According to the final outcome of the disease, the patients were divided into two groups: the cured group and the poor prognosis group. The PCIS scores and PCT,BNP,DD values of children admitted to intensive care unit (PICU) within 24 hours were recorded. The operating characteristic curves (ROC curves) of subjects were drawn for the above indexes, and the area (AUC). Under the respective curves was compared. At the same time, the four indexes were combined to draw the ROC curve, and compared with the AUC of each single index, the advantages and disadvantages of joint diagnosis were evaluated. Results the level of PCT,BNP,DD and the AUC of PCIS within 24 h were between 0. 7 and 0. 9, while the AUC of ROC curve combined with these four indexes were 0. 932, the sensitivity and specificity were improved. Conclusion combined with PCIS score and calcitonin proto-DD level, the accuracy of prognosis assessment in children with severe pneumonia can be improved.
【作者单位】：南京医科大学附属儿童医院呼吸科;扬州大学附属医院儿科;
【分类号】：R725.6

【相似文献】