药物基因组学在甲氨蝶呤治疗儿童急性淋巴细胞白血病中的应用进展
发布时间：2018-09-12 20:37
【摘要】：甲氨蝶呤(MTX)广泛应用于儿童急性淋巴细胞白血病(ALL)的巩固治疗和维持治疗,具有良好的治疗效果,但会引起较严重的不良反应。药物基因组学研究显示,SLCO1B1基因、ABC转运蛋白、叶酰聚谷氨酸合成酶(FPGS)、谷氨酰水解酶(GGH)、亚甲基四氢叶酸还原酶(MTHFR)、胸苷酸合成酶(TYMS或TS)基因多态性与MTX治疗儿童ALL的疗效和不良反应具有相关性。在应用MTX治疗ALL时,应关注影响MTX代谢及转运的相关基因多态性。
[Abstract]:Methotrexate (MTX) is widely used in the consolidation and maintenance of acute lymphoblastic leukemia (ALL) in children. Pharmacogenomics studies showed that the SLCO1B1 gene was a transporter of ABC. The polymorphism of leaf polyglutamic acid synthase (FPGS), glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), thymidine synthase (TYMS or TS) gene was correlated with the therapeutic effect and adverse reaction of MTX in the treatment of ALL in children. In the treatment of ALL with MTX, attention should be paid to the gene polymorphisms that affect the metabolism and transport of MTX.
【作者单位】： 四川省医学科学院·四川省人民医院;电子科技大学医学院;
【基金】：四川省科技基础条件平台基金资助项目(14010159) 2015年四川省人民医院青年科研基金(2015QN08)
【分类号】：R733.71
[Abstract]:Methotrexate (MTX) is widely used in the consolidation and maintenance of acute lymphoblastic leukemia (ALL) in children. Pharmacogenomics studies showed that the SLCO1B1 gene was a transporter of ABC. The polymorphism of leaf polyglutamic acid synthase (FPGS), glutamyl hydrolase (GGH), methylene tetrahydrofolate reductase (MTHFR), thymidine synthase (TYMS or TS) gene was correlated with the therapeutic effect and adverse reaction of MTX in the treatment of ALL in children. In the treatment of ALL with MTX, attention should be paid to the gene polymorphisms that affect the metabolism and transport of MTX.
【作者单位】： 四川省医学科学院·四川省人民医院;电子科技大学医学院;
【基金】：四川省科技基础条件平台基金资助项目(14010159) 2015年四川省人民医院青年科研基金(2015QN08)
【分类号】：R733.71
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1 卢燕;甲氨蝶呤在儿童急性淋巴细胞白血病中的应用进展[J];继续医学教育;2001年02期
2 朱光华;周，
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