过敏性哮喘患儿呼出气一氧化氮变化及与血清过敏原特异性IgE的相关性

发布时间：2018-10-16 11:56

【摘要】：目的观察过敏性哮喘患儿呼出气一氧化氮(FeNO)变化,并探讨其与患儿血清过敏原特异性免疫球蛋白E(s Ig E)的相关性。方法选择2014年1月~016年1月收治的急性发作期过敏性哮喘患儿56例为观察组,非过敏性哮喘患儿56例为对照组。采用FeNO分析仪检测两组患儿FeNO。采用免疫印迹法检测两组患儿血清s Ig E,检测范围包含粉粉尘螨、户尘螨、牛奶、鸡蛋蛋白等共计20种过敏原。分析观察组FeNO与血清s Ig E表达的相关性。结果观察组、对照组患儿FeNO分别为(23.18±3.82)、(5.85±1.19)ppb,两组相比P0.05。观察组总s Ig E阳性38例(67.85%),对照组总s Ig E阳性5例(8.93%),两组相比P0.05。观察组、对照组患儿血清总s Ig E水平分别为(106.51±8.26)、(16.24±2.31)IU/m L,两组相比P0.05。Spearman直线相关分析结果显示观察组患儿FeNO与血清总s Ig E呈正相关(r=0.742,P0.05)。结论过敏性哮喘患儿FeNO高于非过敏性哮喘患儿。过敏性哮喘患儿FeNO与血清s Ig E表达呈正相关。
[Abstract]:Objective to observe the changes of nitric oxide (FeNO) in exhaled air of children with allergic asthma, and to explore the correlation between (FeNO) and serum allergen specific immunoglobulin (E (s Ig E). Methods from January 2014 to January 2006, 56 children with acute allergic asthma and 56 children with non-allergic asthma were selected as observation group and control group respectively. Detection of FeNO. in two groups by FeNO Analyzer The detection range of serum s Ig E, by Western blot was 20 allergens including dust mites, milk and egg proteins. The correlation between FeNO and serum s Ig E expression in observation group was analyzed. Results the FeNO of the observation group and the control group was (23.18 卤3.82), (5.85 卤1.19) ppb, compared with that of the control group (P 0.05). Total s Ig E was positive in 38 cases (67.85%) in the observation group and 5 cases (8.93%) in the control group. The serum total s Ig E levels in the observation group and the control group were (106.51 卤8.26), (16.24 卤2.31) IU/m / L, respectively. Compared with the P0.05.Spearman linear correlation analysis, the results of linear correlation analysis showed that there was a positive correlation between FeNO and total serum s Ig E in the observation group (r = 0.742P 0.05). Conclusion FeNO in children with allergic asthma is higher than that in children with non-allergic asthma. There was a positive correlation between the expression of FeNO and serum s Ig E in children with allergic asthma.
【作者单位】：首都医科大学附属北京朝阳医院;
【分类号】：R725.6

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