米力农在行机械通气的新生儿持续肺动脉高压中的应用效果

发布时间：2018-10-18 16:15

【摘要】：目的探讨米力农在行机械通气的新生儿持续肺动脉高压(PPHN)中的应用效果。方法 80例PPHN患儿随机分为治疗组和对照组,各40例。对照组给予传统机械通气联合枸橼酸西地那非治疗,0.5 mg/(kg·次),1次/6 h,共8次,鼻饲;治疗组给予传统机械通气联合米力农治疗,负荷量20μg/kg,10 min内静注,维持量0.75μg/(kg·min),静滴,两组均治疗48 h。比较两组临床疗效。检测两组治疗前后左心室输出量(SV)、肺动脉压(PAP)、肺动脉平均压(PAMP)、血氧饱和度(Sp O2)、氧合指数(OI)及动脉血氧分压(Pa O2),观察治疗期间不良反应发生情况。结果治疗组总有效率为92.50%,高于对照组的72.50%(χ2=5.541,P=0.019)。治疗后,与对照组比较,治疗组SV、Sp O2、OI及Pa O2高,PAP和PAMP低。两组未见明显不良反应。结论米力农可提高行机械通气治疗的PPHN患儿临床疗效,提高血氧含量、改善持续动脉高压状态,且安全性较好。
[Abstract]:Objective to evaluate the efficacy of milrinone in the treatment of persistent pulmonary hypertension (PPHN) in neonates undergoing mechanical ventilation. Methods 80 children with PPHN were randomly divided into treatment group and control group, 40 cases in each group. The control group was given traditional mechanical ventilation combined with sildenafil citrate, 0.5 mg/ (kg), 8 times per 6 h, nasal feeding, and the treatment group was given traditional mechanical ventilation combined with milrinone, loading 20 渭 g / kg 路kg ~ (-1) 10 min intravenously, maintaining 0.75 渭 g / (kg min), intravenously. Both groups were treated for 48 hours. To compare the clinical effect between the two groups. Left ventricular output (SV),) pulmonary artery pressure (SV), mean pulmonary artery pressure (PAP), (PAMP), oxygen saturation (Sp O 2), oxygenation index (OI) and arterial oxygen partial pressure (Pa O 2) were measured before and after treatment in both groups. Results the total effective rate of the treatment group was 92.50%, which was higher than that of the control group (72.50%) (蠂 ~ 2 = 5.541). After treatment, compared with the control group, the SV,Sp O 2 and Pa O 2 in the treatment group were higher than those in the control group, and PAP and PAMP were lower in the treatment group. No obvious adverse reactions were observed in the two groups. Conclusion milrinone can improve the clinical efficacy of mechanical ventilation in children with PPHN, increase the blood oxygen content, improve the condition of continuous arterial hypertension, and the safety is good.
【作者单位】：广东省妇幼保健院;
【基金】：2017年广东省医学科学技术研究基金支持项目(B2017010)
【分类号】：R722.1

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