从龙温胆汤治疗小儿哮喘慢性持续期（湿滞痰浊型）的临床观察

发布时间：2018-11-01 20:00

【摘要】：目的：观察从龙温胆汤治疗小儿哮喘慢性持续期(湿滞痰浊型)的临床疗效。 方法：将64例哮喘慢性持续期(湿滞痰浊型)患儿随机分为治疗组及对照组各32例,治疗组给予从龙温胆汤口服,对照组给予丙酸倍氯米松气雾剂治疗,以3个月为一疗程。观察两组患儿临床疗效及工gE与CD4+、CD8+的变化。 结果： 治疗3个月后表明：治疗组综合疗效90.63%,而对照组综合疗效为83.33%,两组无显著差异：治疗组改善中医证候疗效优于对照组,P0.05；在减轻哮喘患儿症状、体征总积分方面,治疗组优于对照组,P0.05；治疗组比对照组更能有效地降低IgE及CD4+水平,使CD8+含量上升,P0.05。 结论： 1.临床实验表明从龙温胆汤能够明显改善哮喘慢性持续期湿滞痰浊证 患儿的症状及肺部体征 2.从龙温胆汤能有效的降低CD4+及IgE水平,升高CD8+,这也可能是从龙温胆汤治疗哮喘的机制之一 3.治疗期间患儿无不良反应,药物安全可靠。
[Abstract]:Objective: to observe the clinical effect of Zhonglong Wendan decoction (ZWT) on chronic asthmatic period (dampness stagnation and phlegm turbid type). Methods: 64 children with chronic asthma (dampness stagnation and phlegm turbid type) were randomly divided into treatment group (n = 32) and control group (n = 32). The treatment group was treated with Huilong Wendan decoction and the control group was treated with beclomethasone propionate aerosol for 3 months. The clinical effect and the changes of gE, CD4 and CD8 in the two groups were observed. Results: after 3 months of treatment, the comprehensive curative effect of the treatment group was 90.63 and that of the control group was 83.33. There was no significant difference between the two groups: the curative effect of improving TCM syndrome in the treatment group was better than that in the control group, P 0.05; The treatment group was superior to the control group (P0.05) in alleviating the symptoms and signs of asthmatic children, and the treatment group was more effective than the control group in reducing the levels of IgE and CD4 and increasing the content of CD8 (P0.05). Conclusion: 1. The clinical experiment shows that Zhonlong Wendan decoction can obviously improve the symptoms and pulmonary signs of children with chronic persistent asthmatic dampness stagnation and phlegm turbidity syndrome. Zulong Wendan decoction can effectively reduce the levels of CD4 and IgE and increase CD8, which may also be one of the mechanisms of treatment of asthma from long Wendan decoction. There were no adverse reactions during the treatment and the drugs were safe and reliable.
【学位授予单位】：黑龙江中医药大学
【学位级别】：硕士
【学位授予年份】：2012
【分类号】：R272

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