血清髓鞘碱性蛋白、S100B及血气分析在早产儿脑损伤早期诊断中的价值

发布时间：2018-11-06 12:23

【摘要】：目的:探讨血清髓鞘碱性蛋白(MBP)、S100B及血气分析在早产儿脑损伤早期诊断中的意义。方法:选择于我院住院治疗的95例早产儿作为研究对象,其中符合早产儿脑损伤诊断标准的病例45例作为实验组,无脑损伤的早产儿50例为对照组,所有病例分别在出生后第1天和第7天取动脉血查血气分析,并留取静脉血检测MBD和S100B。结果:实验组血气分析p H、PCO2、乳酸值、BE值和S100B蛋白、MBP的水平第7天与第1天存在明显差异,比较结果显示差异均有统计学意义,第1天分别比较各指标,实验组均高于对照组,比较结果差异均有统计学意义。结论:生后第1天检测动脉血气分析、S100B蛋白和MBP水平能够帮助早期诊断早产儿脑损伤。
[Abstract]:Objective: to investigate the significance of serum myelin basic protein (MBP), S100B) and blood gas analysis in the early diagnosis of brain injury in premature infants. Methods: 95 premature infants who were hospitalized in our hospital were selected as the study objects. Among them, 45 cases met the diagnostic criteria of brain injury of premature infants as experimental group, and 50 cases without brain injury as control group. Arterial blood samples were collected on the 1st and 7th day after birth for blood gas analysis and venous blood samples were taken to detect MBD and S100B. Results: there were significant differences in blood gas analysis between the experimental group and the control group on the 7th day, the first day, the levels of BE, S100B protein, lactic acid, and the level of MBP. The results showed that the differences were statistically significant, and the indexes were compared on the first day. The experimental group was higher than the control group, and the difference was statistically significant. Conclusion: the level of S100B protein and MBP can be helpful in the early diagnosis of brain injury in preterm infants by detecting arterial blood gas analysis on the first day after birth.
【作者单位】：河北医科大学第二医院儿科;河北省人民医院消化科;河北省临西县人民医院儿科;
【基金】：河北省卫生计生委基金资助项目(编号:ZD20150699)
【分类号】：R722.6

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