咖啡因治疗早产儿呼吸暂停远期疗效评价系统综述
发布时间：2018-11-22 13:45
【摘要】：目的:运用系统评价及Meta分析方法,比较咖啡因和安慰剂治疗早产儿呼吸暂(apnea of prematurity,AOP)的远期疗效差别,并分析比较早期和晚期应用咖啡因治疗AOP远期疗效。方法:检索数据库为Pub Med、EMBASE、CNKI、WanFang Data等,时间为2000年1月至2016年6月关于咖啡因与安慰剂对比治疗AOP的文献,和早晚期对比使用咖啡因治疗AOP的研究。采用改良Jadad量表进行质量评价,对符合质量要求的研究纳入研究,使用Stata 11.0统计软件进行Meta分析,合并统计量为RR值、OR值及95%CI。结果:共纳入11个随机对照研究,第一部分5个前瞻性队列研究,咖啡因比安慰剂治疗AOP能显著降低认知障碍(RR=0.887,95%CI:0.813~0.966,P=0.006)、脑瘫(RR=0.581,95%CI:0.437~0.774,P0.001)和动脉导管未闭(RR=0.598,95%CI 0.538~0.665,P=0.000)的发病率,第二部分,6个回顾性队列研究,早期使用咖啡因能显著减低PDA的发病率(OR=0.568,95%CI 0.362~0.892,P=0.014)和支气管肺发育不良的发病率(OR=0.641,95%CI:0.517~0.795,P0.001)。结论:咖啡因治疗AOP能有效降低早产儿的认知障碍、脑瘫和动脉导管未闭(Patent ductus arteriosus,PDA)的发病率,同时在AOP的咖啡治疗中,早期使用比晚期使用更有效降低PDA和支气管肺发育不良(Bronchopulmonary dysplasia,BPD)的发病率。
[Abstract]:Objective: to compare the long-term efficacy of caffeine and placebo in the treatment of respiratory temporary (apnea of prematurity,AOP in premature infants by systematic evaluation and Meta analysis, and to compare the long-term efficacy of caffeine in the treatment of AOP in the early and late stages. Methods: the database was Pub Med,EMBASE,CNKI,WanFang Data et al., from January 2000 to June 2016, the literature on the comparative treatment of caffeine and placebo on AOP, and the study on the treatment of AOP with caffeine in the morning and evening. The modified Jadad scale was used to evaluate the quality, the research according to the quality requirements was included in the study, and the Meta analysis was carried out by using Stata 11.0 statistical software. The combined statistics were RR, OR and 95 CIs. Results: in 11 randomized controlled trials, the first part of 5 prospective cohort studies showed that caffeine significantly reduced cognitive impairment (RR=0.887,95%CI:0.813~0.966,P=0.006) compared with placebo. Incidence of cerebral palsy (RR=0.581,95%CI:0.437~0.774,P0.001) and patent ductus arteriosus (RR=0.598,95%CI 0.538 / 0.665P0.000), part II, 6 retrospective cohort studies, Early use of caffeine significantly reduced the incidence of PDA (OR=0.568,95%CI 0.362) and bronchopulmonary dysplasia (OR=0.641,95%CI:0.517~0.795,P0.001). Conclusion: caffeine treatment for AOP can effectively reduce the incidence of cognitive impairment, cerebral palsy and patent ductus arteriosus (Patent ductus arteriosus,PDA) in premature infants. Early use is more effective than late use in reducing the incidence of PDA and bronchopulmonary dysplasia (Bronchopulmonary dysplasia,BPD).
【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R722.6
本文编号：2349543
[Abstract]:Objective: to compare the long-term efficacy of caffeine and placebo in the treatment of respiratory temporary (apnea of prematurity,AOP in premature infants by systematic evaluation and Meta analysis, and to compare the long-term efficacy of caffeine in the treatment of AOP in the early and late stages. Methods: the database was Pub Med,EMBASE,CNKI,WanFang Data et al., from January 2000 to June 2016, the literature on the comparative treatment of caffeine and placebo on AOP, and the study on the treatment of AOP with caffeine in the morning and evening. The modified Jadad scale was used to evaluate the quality, the research according to the quality requirements was included in the study, and the Meta analysis was carried out by using Stata 11.0 statistical software. The combined statistics were RR, OR and 95 CIs. Results: in 11 randomized controlled trials, the first part of 5 prospective cohort studies showed that caffeine significantly reduced cognitive impairment (RR=0.887,95%CI:0.813~0.966,P=0.006) compared with placebo. Incidence of cerebral palsy (RR=0.581,95%CI:0.437~0.774,P0.001) and patent ductus arteriosus (RR=0.598,95%CI 0.538 / 0.665P0.000), part II, 6 retrospective cohort studies, Early use of caffeine significantly reduced the incidence of PDA (OR=0.568,95%CI 0.362) and bronchopulmonary dysplasia (OR=0.641,95%CI:0.517~0.795,P0.001). Conclusion: caffeine treatment for AOP can effectively reduce the incidence of cognitive impairment, cerebral palsy and patent ductus arteriosus (Patent ductus arteriosus,PDA) in premature infants. Early use is more effective than late use in reducing the incidence of PDA and bronchopulmonary dysplasia (Bronchopulmonary dysplasia,BPD).
【学位授予单位】：皖南医学院
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R722.6
【参考文献】
相关期刊论文 前1条
1 Hesham Abdel-Hady;Nehad Nasef;Abd Elazeez Shabaan;Islam Nour;;Caffeine therapy in preterm infants[J];World Journal of Clinical Pediatrics;2015年04期
，本文编号：2349543
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