活性炭联合营养干预治疗儿童铅中毒的疗效观察

发布时间：2018-11-26 12:24

【摘要】：[目的]探讨活性炭联合营养干预对儿童铅中毒的治疗效果。[方法]选择在某院门诊就诊的儿童铅中毒病例(血铅水平在100~249μg/L范围内,未进行过药物驱铅治疗)77人,按就诊顺序随机分为联合治疗组(39人)和常规治疗组(38人)。常规治疗组给予常规营养干预(钙250 mg/d、锌10 mg/d、维生素C 200 mg/d、维生素B1 5 mg/d,每日睡前一次口服);联合治疗组在常规治疗组治疗基础上加用活性炭片0.9 g/次,餐前口服,3次/日。连续干预治疗30 d,观察两组治疗结束时、治疗结束后第30天的血铅水平。[结果]治疗结束时,联合治疗组儿童血铅水平降至正常范围(98.13μg/L),低于常规治疗组118.10μg/L(P0.05);治愈25例,治愈率为64.1%,明显高于常规治疗组的28.9%(P0.01)。治疗结束后第30天,联合治疗组血铅水平持续下降至68.75μg/L,而常规治疗组下降趋势明显变缓,降至108.77μg/L;2组治愈率分别为82.1%和42.1%。[结论]活性炭联合营养干预可明显降低铅中毒儿童的血铅水平。
[Abstract]:[objective] to explore the therapeutic effect of active carbon combined with nutritional intervention on lead poisoning in children. [methods] 77 children with lead poisoning (blood lead level in the range of 100 ~ 249 渭 g / L) were randomly divided into combined treatment group (39 patients) and routine treatment group (38 patients). Routine nutrition intervention was given in the routine treatment group (calcium 250 mg/d, zinc 10 mg/d, vitamin C 200 mg/d, vitamin B15 mg/d, daily before bedtime); Combined treatment group in the routine treatment group on the basis of the addition of 0.9 g / time of activated carbon tablet, oral before meal, 3 times a day. After 30 days of continuous intervention, the blood lead levels were observed at the end of treatment in both groups. [results] at the end of the treatment, the level of blood lead in the combined treatment group decreased to the normal range (98.13 渭 g / L), which was lower than that in the routine treatment group (118.10 渭 g / L) (P0.05). 25 cases were cured, the cure rate was 64.1%, which was significantly higher than that of routine treatment group (28.9%, P0.01). On the 30th day after treatment, the blood lead level in the combined treatment group continued to decrease to 68.75 渭 g / L, while that in the routine treatment group slowed down significantly to 108.77 渭 g / L, the cure rates of the two groups were 82.1% and 42.1%, respectively. [conclusion] combined nutritional intervention with activated carbon can significantly reduce the blood lead level of children with lead poisoning.
【作者单位】：江西省职业病防治研究院职业病医院;
【基金】：江西省卫生计生委科技计划(编号:20162005)
【分类号】：R725.9

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