248例住院过敏性紫瘢患儿血液中EB病毒载量的检测和分析

发布时间：2018-11-29 13:18

【摘要】：[目的]分析过敏性紫癜与EB病毒感染的关系,为以后临床诊断及治疗提供依据。[方法]用回顾性调查的方法,收集2014年2月至2016年1月住院诊断为HSP患儿的临床资料和EB病毒载量测定的结果,根据临床特点把患儿分为单纯型、腹型、肾型、关节型、混合型,对发病年龄及性别、住院天数、发病季节、EB病毒载量及EB病毒阳性比进行统计分析,所有数据经统计学方法处理。[结果]在248例HSP患儿中,男性147例(59. 3%),女性101例(40. 7%)。年龄为2~16岁,平均年龄8. 89±2.89岁,1岁到3岁4例,3岁到6岁58例,7岁至10岁107例,≥11岁79例。发病季节,春季(2-4 月)76 例(30.6%),夏季(5-7 月)36 例(14.5%),秋季(8-10 月)56 例(22.6%),冬季(11 月-1 月)79 例(32. 3%),不同季节EBV阳性检出率差异有统计学意义,春冬季明显高于秋季。其中单纯型35例(14. 1%),腹型37例(14. 9%),肾型74例(29. 8%),关节型36例(14.5%),混合型66例(26.7%)。EB病毒阳性共105例,阳性率42%。病毒载量范围为4. 08×102-8.6×105拷贝/ml,其中4. 0X 102-4. 0X 103的有 51 人(48.6%),4.0X 103-4. 0X 104拷贝/ml的有 45 人(42. 9%),4. 0× 104-4. 0× 105拷贝/ml 的有 8 人(7. 6%),4. 0× 105-4. 0× 106拷贝/ml的有1人(0.9%),病毒载量介于4. 0X 102-4. 0×103拷贝/ml所占比例最大。相对应地,EB病毒感染单纯型14例(13.3%),腹型16例(15.2%),肾型28例(26.6%),关节型17例(16. 2%),混合型30例(28. 7%),各类型间EB病毒感染阳性比无显著差异。HSP住院天数3~43天,平均住院天数10.91±6.64天。EB病毒阳性患儿的住院天数(17.12天)明显高于阴性患儿(12.96天)。[结论]1、HSP发病男童高于女童,以学龄儿童多见,以春冬季为主。2、HSP患儿EB病毒阳性检出率高,EB病毒阳性可致患儿住院时间延长。3、不同季节HSP患儿EB阳性检出率不同,春冬季明显高于秋季,应加强个人卫生以预防EB病毒感染。
[Abstract]:Objective: to analyze the relationship between Henoch-Schonlein purpura and EB virus infection in order to provide basis for clinical diagnosis and treatment. [methods] from February 2014 to January 2016, the clinical data and the results of EB viral load determination in hospitalized children with HSP were collected and classified into simple type, abdominal type, renal type and articular type by retrospective investigation. The age and sex of the disease, the days of hospitalization, the season of onset, the load of EB virus and the positive ratio of EB virus were statistically analyzed. All the data were processed by statistical method. [results] among 248 cases of HSP, 147 cases (59. 7%) were male. (3%), 101 female (40. 5%). 7%) The average age is 8. 5%. 89 卤2.89 years old, 1 to 3 years old in 4 cases, 3 to 6 years old in 58 cases, 7 to 10 years old in 107 cases, 鈮，

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