血浆半乳糖凝集素-3在川崎病中的水平及其与冠脉损伤的相关性研究
发布时间：2019-01-04 13:17
【摘要】：目的:观察川崎病(kawasaki disease,KD)患儿不同时期血浆半乳糖凝集素-3(Galectin-3,Gal-3)的水平及其与冠脉病变(coronary arterial lesions,CAL)的关系。方法:测定50例KD患儿急性期(发病11天,人丙种球蛋白使用前)、亚急性期(病程的11-21天,IVIG使用后,体温正常)和20例年龄相仿门诊体检的健康儿童的血浆Gal-3的水平,同时记录患儿的一般临床资料如PLT、ESR、CRP。并根据是否发生CAL分组分析患儿血浆Gal-3的水平变化,并分析其与血小板计数(PLT)、血沉(ESR)、C反应蛋白(CRP)的相关性。结果:KD患儿急性期、亚急性期血浆Gal-3浓度分别为(14.64±1.99)ng/ml、(11.89±1.25)ng/ml,健康体检儿童血浆Gal-3浓度为(10.15±0.79)ng/ml。KD患儿急性期、亚急性期血浆Gal-3浓度均明显高于健康体检儿童(P0.05);急性期明显高于亚急性期,(P0.05);急性期冠脉病变组(CAL组,n=17)和非冠脉病变组(NCAL组,n=33)血浆Gal-3的浓度分别为(16.40±1.21)ng/ml、(13.77±1.48)ng/ml,CAL组高于NCAL组(P0.05);同时KD患儿急性期血浆Gal-3水平与PLT、CRP水平呈正相关关系(P0.05)。结论:KD患儿血浆Gal-3水平急性期显著升高,并随病程下降,急性期CAL组血浆Gal-3水平高于NCAL组,血浆Gal-3急性期显著升高对于患儿冠状动脉损害有一定的预测意义或可辅助川崎病的诊断。
[Abstract]:Aim: to investigate the relationship between plasma galactose agglutinin 3 (Galectin-3,Gal-3) and coronary artery disease (coronary arterial lesions,CAL) in children with Kawasaki disease (kawasaki disease,KD). Methods: the acute phase (11 days of onset, before the use of human gamma globulin) and the subacute phase (11-21 days of course of disease, after the use of IVIG) were measured in 50 cases of KD. (normal body temperature) and 20 healthy children of similar age for outpatient check-up, plasma Gal-3 levels were recorded, and general clinical data such as PLT,ESR,CRP. were recorded. The level of plasma Gal-3 was analyzed according to whether CAL occurred or not, and the correlation between the level of plasma Gal-3 and (PLT), ESR (ESR), C reactive protein (CRP) was analyzed. Results: the plasma Gal-3 concentrations in children with KD were (14.64 卤1.99) ng/ml, (11.89 卤1.25) ng/ml, in acute phase and (11.89 卤1.25) ng/ml, in subacute phase, respectively. The plasma Gal-3 concentration of healthy children was (10.15 卤0.79) ng/ml.KD in acute stage, and the plasma Gal-3 concentration in subacute phase was significantly higher than that in healthy children (P0.05). The acute stage was significantly higher than the subacute stage (P0.05). The plasma Gal-3 levels in acute coronary lesion group (CAL group, nong17) and non-coronary lesion group (NCAL group, nong33 group) were (16.40 卤1.21) ng/ml, (13.77 卤1.48) ng/ml,CAL group and (16.40 卤1.21) ng/ml, (13.77 卤1.48) ng/ml,CAL group, respectively (P0.05). At the same time, there was a positive correlation between plasma Gal-3 level and PLT,CRP level in children with KD (P0.05). Conclusion: the plasma Gal-3 level in children with KD increased significantly in acute phase, and decreased with the course of disease. The plasma Gal-3 level in CAL group was higher than that in NCAL group in acute phase. The significant increase of plasma Gal-3 in acute phase may predict coronary artery damage in children or assist the diagnosis of Kawasaki disease.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.4
[Abstract]:Aim: to investigate the relationship between plasma galactose agglutinin 3 (Galectin-3,Gal-3) and coronary artery disease (coronary arterial lesions,CAL) in children with Kawasaki disease (kawasaki disease,KD). Methods: the acute phase (11 days of onset, before the use of human gamma globulin) and the subacute phase (11-21 days of course of disease, after the use of IVIG) were measured in 50 cases of KD. (normal body temperature) and 20 healthy children of similar age for outpatient check-up, plasma Gal-3 levels were recorded, and general clinical data such as PLT,ESR,CRP. were recorded. The level of plasma Gal-3 was analyzed according to whether CAL occurred or not, and the correlation between the level of plasma Gal-3 and (PLT), ESR (ESR), C reactive protein (CRP) was analyzed. Results: the plasma Gal-3 concentrations in children with KD were (14.64 卤1.99) ng/ml, (11.89 卤1.25) ng/ml, in acute phase and (11.89 卤1.25) ng/ml, in subacute phase, respectively. The plasma Gal-3 concentration of healthy children was (10.15 卤0.79) ng/ml.KD in acute stage, and the plasma Gal-3 concentration in subacute phase was significantly higher than that in healthy children (P0.05). The acute stage was significantly higher than the subacute stage (P0.05). The plasma Gal-3 levels in acute coronary lesion group (CAL group, nong17) and non-coronary lesion group (NCAL group, nong33 group) were (16.40 卤1.21) ng/ml, (13.77 卤1.48) ng/ml,CAL group and (16.40 卤1.21) ng/ml, (13.77 卤1.48) ng/ml,CAL group, respectively (P0.05). At the same time, there was a positive correlation between plasma Gal-3 level and PLT,CRP level in children with KD (P0.05). Conclusion: the plasma Gal-3 level in children with KD increased significantly in acute phase, and decreased with the course of disease. The plasma Gal-3 level in CAL group was higher than that in NCAL group in acute phase. The significant increase of plasma Gal-3 in acute phase may predict coronary artery damage in children or assist the diagnosis of Kawasaki disease.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R725.4
【参考文献】
相关期刊论文 前10条
1 吴增城;康利民;李阳;郭斌;冯磊;彭青;潘明新;;半乳糖凝集素-3联合HGF诱导大鼠骨髓间充质干细胞分化为肝样细胞[J];重庆医学;2016年15期
2 徐永龙;丁金旺;周荣t，
本文编号：2400340
本文链接：https://www.wllwen.com/yixuelunwen/eklw/2400340.html
最近更新
教材专著
