海口地区小儿呼吸道病原体检测结果分析
发布时间：2019-01-05 12:45
【摘要】：目的：对海南省中医院、海口市人民医院住院及门诊的小儿呼吸道感染患者检测9种病原体抗体并进行结果分析,探讨海口地区小儿呼吸道患者9种病原体的流行分布情况,不同年龄组、不同性别、不同季节病原体的检出情况,为海口地区小儿呼吸道疾病预防策略制定、临床诊断及治疗提供病原学实验室依据。 方法：收集2013年1月至2013年12月在海南省中医院、海口市人民医院住院及门诊小儿呼吸道感染患者1144例,按照小儿的年龄分期标准,分为4个年龄组。应用间接免疫荧光法同时对9种病原体行血清IgM抗体联合检测及分析研究,这9种病原体分别为嗜肺军团菌(LP),肺炎支原体(MP),Q热立克次体(COX),肺炎衣原体(CPm),腺病毒(AdV),呼吸道合胞病毒(RSV),甲型流感病毒(INFA)和乙型流感病毒(INFB),副流感病毒(PIVs)。 结果：1.1144例患者血清样本中,检出IgM抗体阳性536例,阳性率为46.85%。单项感染339例,阳性率为29.63%。 2.单项感染排前三位的分别是MP,阳性率为22.5%(258/1144)、INFB,阳性率为4.11%(47/1144)、LP阳性率为2.27%(26/1144)。混合感染197例,以MP+INFB感染为主,占10.23%(117/1144)：其次为LP+MP混合感染,阳性率为2.62%(30/1144)；第三位是LP+MP+INFB混合感染,阳性率为1.92%(22/1144)；其阳性率和构成比均不同(P0.05)。 3.4个年龄组阳性率随年龄增加而增加,学龄前期组感染阳性率高,为73.06%(198/270),其次为幼儿组,阳性率为63.00%(126/200),第三位为婴儿后期组,阳性率为48.93%(183/374),各组阳性率及构成比均不相同(P0.05)。 4.1144个病例中,检出536例病原体抗体呈阳性反应,其中男性326例,阳性率为41.85%,构成比为0.61；女性210例,阳性率为57.53%,男性和女性感染的阳性率和构成比均不同(P0.05)。在男性混合感染中,阳性率排在前三位的分别为MP+INFB(阳性率为7.96%)、LP+MP(阳性率为2.70%)和LP+MP+INFB(1.41%)。在女性混合感染中,阳性率排在前三位的分别为MP+INFB(阳性率为15.07%)、LP+MP+INFB(阳性率为3.01%)和LP+MP(阳性率为2.47%),三种组合的病原体间感染阳性率及构成比均各不同(P0.05),同种病原体在不同性别中感染阳性率各不同(P0.05)。 5.四个季节中,夏季感染阳性率高达51.84%,构成比为0.32；秋季为50.16%,春季为48.34,冬季为31.16%。经卡方检验,与冬季相比,其他三个季节阳性率和构成比均显著上升(P0.05),而夏季与秋季间阳性率与构成比均无显著差异(P0.05)。在春季,9种病原体感染阳性率前三位分别为MP、MP+INFB、MP+LP。在夏季,9种病原体感染阳性率前三位分别为MP、MP+INFB、INFB。在秋季,9种病原体感染阳性率前三位分别为MP、MP+INFB、INFB。在冬季,9种病原体感染阳性率前三位分别为MP、LP、INFB。选择感染阳性率较高的4种感染类型,分别为MP、LP、INFB、MP+INFB,分析其在各季节中阳性率差异。MP感染的阳性率在夏季显著上升(P0.05),LP感染的阳性率在冬季显著上升(P0.05),INFB感染的阳性率在秋季显著上升(P0.05),MP+INFB感染的阳性率在秋季显著上升(P0.05)。 结论：1.海口地区9种小儿呼吸道病原体,单项感染以肺炎支原体感染为常见,混合感染以肺炎支原体合并乙型流感病毒感染为主,单项感染多于混合感染。 2.9种小儿呼吸道病原体感染在不同年龄段的阳性率有显著不同,学龄前期组最高,婴儿前期组最低。 3.男性和女性感染的阳性率和构成比均不同。 4.9种小儿呼吸道病原体流行还与季节有关。 5.该研究为海口地区预防策略制定、临床诊断、合理用药提供病原学实验室依据。
[Abstract]:Objective: To study the prevalence and distribution of 9 pathogens in children with respiratory tract infection in the hospital of Hainan, the hospital of the people's hospital in Haikou, and in the clinic, and to study the distribution of 9 pathogens in the children's respiratory tract of Haikou. The detection of pathogens in different seasons provides a basis for the development, clinical diagnosis and treatment of children's respiratory diseases in Haikou. Methods: A total of 1144 children with respiratory tract infection were collected from January 2013 to December 2013 in the middle hospital of Hainan Province, the hospital of the people's hospital of Haikou City and the children with respiratory tract infection in the clinic. The results of the combined detection and analysis of the serum IgM antibodies in 9 pathogens were carried out by indirect immunofluorescence. The nine pathogens were pneumophila (LP), Mycoplasma hyopneumoniae (MP), Q-thermogram subbody (COX), Chlamydia pneumoniae (CPm), and adenovirus (AdV).), Respiratory Syncytial Virus (RSV), Influenza A (INFA) and Influenza B (INFB), Parainfluenza Virus (PIVs) Results: In the serum samples of 1,1144 patients, the positive rate of IgM antibody was found in 536 cases, and the positive rate was 46. The positive rate was 29 in 339 cases of single infection. The positive rate was 22. 5% (258/ 1144), the positive rate of INFB was 4.11% (47/ 1144), and the positive rate of LP was 2.27% (26/ 120). The positive rate of the mixed infection was 2.62% (30/ 1144), the positive rate was 1.92% (22/ 1144), the positive rate and the composition ratio were different (P (0.05). The positive rate of the 4 age groups increased with the age, the positive rate of the infection in the pre-school group was high, it was 73.06% (198/ 270), the second was the infant group, the positive rate was 63. 00% (126/ 200), the third was the late group of the baby, the positive rate was 48.93% (183/ 374), the positive rate and the composition ratio of each group were not the same. (P0.05). Among the 1144 cases, 536 cases of pathogen antibody were positive, of which 326 were male, the positive rate was 41. 85%, the composition ratio was 0.61, the positive rate was 57. 53%, and the positive rate and the composition ratio of male and female infection were all. In male mixed infection, the positive rate was MP + INFB (positive rate was 7.96%), and LP + MP (positive rate was 2.70%) and LP + MP + IN. The positive rate of positive rate in female mixed infection was MP + INFB (positive rate was 15.07%), LP + MP + INFB (positive rate was 3.01%) and LP + MP (positive rate was 2.47%), and the positive rate and composition ratio of the three combinations were all. The positive rate of the same pathogen in different sex was different (P0.05). In the four seasons, the positive rate of infection in summer was 51. 84%, the composition ratio was 0.32, the fall was 50. 16%, and the spring was 48. 3. 4, 31. 16% in winter. The positive rate and composition ratio of the other three seasons were significantly higher than that in winter (P0.05), while the positive rate and composition ratio in summer and autumn were none. There were significant differences (P0.05). In spring, the positive rate of 9 pathogens was MP, MP, respectively. + INFB, MP + LP. In summer, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In autumn, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In winter, the positive rate of nine pathogens was the first three. Four types of infection were selected for MP, LP, INFB, MP, LP, INFB, MP + INFB. The positive rate of the infection was significantly higher in the summer (P0.05). The positive rate of the infection was significantly higher in the winter (P0.05). The positive rate of INFB infection increased significantly in the autumn (P0.05). The positive rate of the infection of MP + INFB was in the fall. a significant increase (Conclusion: 1. The infection of 9 children's respiratory pathogens in the Haikou area is common with the mycoplasma pneumoniae infection, and the mixed infection is the combination of the mycoplasma pneumoniae and the influenza B virus infection. 2. The positive rate of respiratory pathogens in 9 children was significantly different in different age groups. The highest in the pre-school group and the lowest in the early-stage group. The positive rate and composition ratio of sex and female infection are different. 9. The prevalence of respiratory pathogens in 9 children is also related to the season.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R725.6
本文编号：2401799
[Abstract]:Objective: To study the prevalence and distribution of 9 pathogens in children with respiratory tract infection in the hospital of Hainan, the hospital of the people's hospital in Haikou, and in the clinic, and to study the distribution of 9 pathogens in the children's respiratory tract of Haikou. The detection of pathogens in different seasons provides a basis for the development, clinical diagnosis and treatment of children's respiratory diseases in Haikou. Methods: A total of 1144 children with respiratory tract infection were collected from January 2013 to December 2013 in the middle hospital of Hainan Province, the hospital of the people's hospital of Haikou City and the children with respiratory tract infection in the clinic. The results of the combined detection and analysis of the serum IgM antibodies in 9 pathogens were carried out by indirect immunofluorescence. The nine pathogens were pneumophila (LP), Mycoplasma hyopneumoniae (MP), Q-thermogram subbody (COX), Chlamydia pneumoniae (CPm), and adenovirus (AdV).), Respiratory Syncytial Virus (RSV), Influenza A (INFA) and Influenza B (INFB), Parainfluenza Virus (PIVs) Results: In the serum samples of 1,1144 patients, the positive rate of IgM antibody was found in 536 cases, and the positive rate was 46. The positive rate was 29 in 339 cases of single infection. The positive rate was 22. 5% (258/ 1144), the positive rate of INFB was 4.11% (47/ 1144), and the positive rate of LP was 2.27% (26/ 120). The positive rate of the mixed infection was 2.62% (30/ 1144), the positive rate was 1.92% (22/ 1144), the positive rate and the composition ratio were different (P (0.05). The positive rate of the 4 age groups increased with the age, the positive rate of the infection in the pre-school group was high, it was 73.06% (198/ 270), the second was the infant group, the positive rate was 63. 00% (126/ 200), the third was the late group of the baby, the positive rate was 48.93% (183/ 374), the positive rate and the composition ratio of each group were not the same. (P0.05). Among the 1144 cases, 536 cases of pathogen antibody were positive, of which 326 were male, the positive rate was 41. 85%, the composition ratio was 0.61, the positive rate was 57. 53%, and the positive rate and the composition ratio of male and female infection were all. In male mixed infection, the positive rate was MP + INFB (positive rate was 7.96%), and LP + MP (positive rate was 2.70%) and LP + MP + IN. The positive rate of positive rate in female mixed infection was MP + INFB (positive rate was 15.07%), LP + MP + INFB (positive rate was 3.01%) and LP + MP (positive rate was 2.47%), and the positive rate and composition ratio of the three combinations were all. The positive rate of the same pathogen in different sex was different (P0.05). In the four seasons, the positive rate of infection in summer was 51. 84%, the composition ratio was 0.32, the fall was 50. 16%, and the spring was 48. 3. 4, 31. 16% in winter. The positive rate and composition ratio of the other three seasons were significantly higher than that in winter (P0.05), while the positive rate and composition ratio in summer and autumn were none. There were significant differences (P0.05). In spring, the positive rate of 9 pathogens was MP, MP, respectively. + INFB, MP + LP. In summer, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In autumn, the positive rate of 9 pathogens was MP, M, respectively. The positive rate of P + INFB, INFB. In winter, the positive rate of nine pathogens was the first three. Four types of infection were selected for MP, LP, INFB, MP, LP, INFB, MP + INFB. The positive rate of the infection was significantly higher in the summer (P0.05). The positive rate of the infection was significantly higher in the winter (P0.05). The positive rate of INFB infection increased significantly in the autumn (P0.05). The positive rate of the infection of MP + INFB was in the fall. a significant increase (Conclusion: 1. The infection of 9 children's respiratory pathogens in the Haikou area is common with the mycoplasma pneumoniae infection, and the mixed infection is the combination of the mycoplasma pneumoniae and the influenza B virus infection. 2. The positive rate of respiratory pathogens in 9 children was significantly different in different age groups. The highest in the pre-school group and the lowest in the early-stage group. The positive rate and composition ratio of sex and female infection are different. 9. The prevalence of respiratory pathogens in 9 children is also related to the season.
【学位授予单位】：中南大学
【学位级别】：硕士
【学位授予年份】：2014
【分类号】：R725.6
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