C反应蛋白、前清蛋白联合白细胞计数在新生儿感染性疾病中的诊断及应用

发布时间：2019-01-06 17:33

【摘要】：目的探讨C反应蛋白(CRP)、血清前清蛋白(PA)及白细胞计数(WBC)联合检测对于新生儿感染性疾病的诊断及临床应用价值。方法收集187例足月新生患儿,其中92例细菌感染患儿作为感染组,95例非感染性疾病患儿作为非感染组,检测CRP、PA及WBC分别在两组中所占异常率;比较单项及联合应用的敏感度和特异度及假阳性率和假阴性率;观察比较感染组患儿3种指标治疗前后的变化情况。结果感染组新生儿的CRP、PA及WBC异常率均明显高于非细菌感染性疾病组(P0.05);联合检测CRP+PA+WBC较单独检测CRP、PA、WBC的灵敏度和特异度高;治疗后,感染组新生儿CRP水平显著降低,PA水平明显升高,WBC计数恢复正常(P0.05)。结论 CRP、PA及WBC联合检测对早期诊断新生儿细菌性感染具有重要的临床价值。
[Abstract]:Objective to investigate the diagnostic and clinical value of C reactive protein (CRP),) prealbumin (PA) and white blood cell count (WBC) in neonatal infectious diseases. Methods the abnormal rates of CRP,PA and WBC were detected in 187 full-term newborns, including 92 cases of bacterial infection as infection group and 95 cases of non-infectious disease as non-infection group. The sensitivity, specificity, false positive rate and false negative rate of single and combined use were compared, and the changes of the three indexes before and after treatment were observed and compared. Results the abnormal rates of CRP,PA and WBC in infected neonates were significantly higher than those in non-bacterial infectious diseases (P0.05), and the sensitivity and specificity of combined detection of CRP PA WBC were higher than those of CRP,PA,WBC alone. After treatment, the level of CRP decreased significantly, the level of PA increased significantly and the WBC count returned to normal in infected group (P0.05). Conclusion the combined detection of CRP,PA and WBC has important clinical value in the early diagnosis of neonatal bacterial infection.
【作者单位】：重庆市北碚区妇幼保健院;
【分类号】：R722.13

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