双胞胎青少年特发性脊柱侧凸的发病特点
发布时间：2019-01-26 18:21
【摘要】：目的 :观察青少年特发性脊柱侧凸(adolescent idiopathic scoliosis,AIS)双胞胎的共同发病率,比较同卵双胞胎之间的发病特点。方法:2007年1月~2016年12月期间我院收录同时患有AIS的双胞胎患者21对,其中女19对(含三胞胎1例),男2对,记录其初诊年龄、女性月经初潮年龄、BMI、Cobb角、胸椎后凸角、腰椎前凸角、Risser征等资料。通过短串联重复序列检测明确区分同卵双胞胎与异卵双胞胎,比较同卵双胞胎和异卵双胞胎的AIS共同发病率。选取同卵双胞胎中两人Cobb角差值≥10°的病例,将其中度数大者纳入侧凸较大组,度数小者纳入侧凸较小组,采用配对样本t检验比较两组之间初潮年龄、BMI、Risser征临床资料的差异。结果:21对双胞胎平均初诊年龄13.2±2.5岁,女性月经初潮年龄12.2±1.4岁,初诊时平均Cobb角29.2°±14.8°,胸椎后凸角16.8°±9.2°,腰椎前凸角45.5°±7.4°,BMI 17.0±1.6kg/m2,Risser征2.3±1.6。21对双胞胎中同卵双胞胎17对,异卵双胞胎4对。同卵双胞胎中16对(94.1%)共同患有AIS,11对(68.8%)弯型一致,4对(25.0%)Cobb角差值小于10°。异卵双胞胎中3对(75.0%)共同患有AIS,1对(33.3%)弯型一致,1对(33.3%)Cobb角差值小于10°。同卵双胞胎中Cobb角差值≥10°者12对,侧凸较大组的月经初潮年龄和BMI均小于侧凸较小组(P0.05),Risser征两组之间无统计学差异(P0.05)。结论 :同卵双胞胎AIS患者共同发病率较高(94.1%)且弯型一致,但同卵双胞胎两者间畸形严重程度不一,双胞胎中畸形较重者的月经初潮年龄较小、BMI较低。
[Abstract]:Objective: to observe the common incidence of adolescent idiopathic scoliosis (adolescent idiopathic scoliosis,AIS) twins and compare the characteristics of identical twins. Methods: from January 2007 to December 2016, 21 pairs of twins with AIS were enrolled in our hospital, including 19 pairs of women (including 1 case of triplets) and 2 pairs of men. The age of first diagnosis, the age of menarche in women, the angle of BMI,Cobb, the kyphoid angle of thoracic vertebrae were recorded. Lumbar kyphosis angle, Risser sign and so on. The common incidence of AIS was compared between identical twins and fraternal twins by short tandem repeat (STR) detection. Two cases of identical twins whose Cobb angle difference was greater than 10 掳were selected, in which the larger degree was included in the greater group of scoliosis and the lesser degree was included in the group of scoliosis. The age of menarche between the two groups was compared by paired sample t test, BMI,. The difference of clinical data of Risser sign. Results: the mean age at first visit of 21 twins was 13.2 卤2.5 years old, the menarche age of females was 12.2 卤1.4 years old, the mean Cobb angle was 29.2 掳卤14.8 掳, the thoracic kyphosis angle was 16.8 掳卤9.2 掳, and the lumbar kyphosis angle was 45.5 掳卤7.4 掳. BMI 17.0 卤1.6kg / m2 risser's sign 2.3 卤1.6.21 pairs of twins 17 pairs of identical twins and 4 pairs of fraternal twins. Among the identical twins, 16 pairs (94.1%) had the same AIS,11 pair (68.8%) and 4 pairs (25.0%) had a difference of Cobb angle less than 10 掳. Among fraternal twins, 3 pairs (75.0%) had the same AIS,1 pair (33.3%) and 1 pair (33.3%) had a difference of Cobb angle less than 10 掳. In 12 pairs of identical twins whose Cobb angle difference was more than 10 掳, menarche age and BMI in the larger scoliosis group were lower than those in the group with scoliosis (P0.05), Risser sign had no statistical difference between the two groups (P0.05). Conclusion: the incidence of AIS in identical twins is high (94.1%) and the concave type is the same. However, the degree of malformation between identical twins is different. The age of menarche and BMI are lower in the patients with severe malformation of identical twins.
【作者单位】： 南京大学医学院附属鼓楼医院脊柱外科;
【基金】：江苏省卫生厅临床医学中心资助项目
【分类号】：R726.8
，
本文编号：2415767
[Abstract]:Objective: to observe the common incidence of adolescent idiopathic scoliosis (adolescent idiopathic scoliosis,AIS) twins and compare the characteristics of identical twins. Methods: from January 2007 to December 2016, 21 pairs of twins with AIS were enrolled in our hospital, including 19 pairs of women (including 1 case of triplets) and 2 pairs of men. The age of first diagnosis, the age of menarche in women, the angle of BMI,Cobb, the kyphoid angle of thoracic vertebrae were recorded. Lumbar kyphosis angle, Risser sign and so on. The common incidence of AIS was compared between identical twins and fraternal twins by short tandem repeat (STR) detection. Two cases of identical twins whose Cobb angle difference was greater than 10 掳were selected, in which the larger degree was included in the greater group of scoliosis and the lesser degree was included in the group of scoliosis. The age of menarche between the two groups was compared by paired sample t test, BMI,. The difference of clinical data of Risser sign. Results: the mean age at first visit of 21 twins was 13.2 卤2.5 years old, the menarche age of females was 12.2 卤1.4 years old, the mean Cobb angle was 29.2 掳卤14.8 掳, the thoracic kyphosis angle was 16.8 掳卤9.2 掳, and the lumbar kyphosis angle was 45.5 掳卤7.4 掳. BMI 17.0 卤1.6kg / m2 risser's sign 2.3 卤1.6.21 pairs of twins 17 pairs of identical twins and 4 pairs of fraternal twins. Among the identical twins, 16 pairs (94.1%) had the same AIS,11 pair (68.8%) and 4 pairs (25.0%) had a difference of Cobb angle less than 10 掳. Among fraternal twins, 3 pairs (75.0%) had the same AIS,1 pair (33.3%) and 1 pair (33.3%) had a difference of Cobb angle less than 10 掳. In 12 pairs of identical twins whose Cobb angle difference was more than 10 掳, menarche age and BMI in the larger scoliosis group were lower than those in the group with scoliosis (P0.05), Risser sign had no statistical difference between the two groups (P0.05). Conclusion: the incidence of AIS in identical twins is high (94.1%) and the concave type is the same. However, the degree of malformation between identical twins is different. The age of menarche and BMI are lower in the patients with severe malformation of identical twins.
【作者单位】： 南京大学医学院附属鼓楼医院脊柱外科;
【基金】：江苏省卫生厅临床医学中心资助项目
【分类号】：R726.8
，
本文编号：2415767
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