基于中医传承辅助系统探讨小儿病毒性肺炎的组方用药规律

发布时间：2019-02-13 19:59

【摘要】：目的:基于“中医传承辅助系统(V2.5)”软件,对小儿病毒性肺炎的方剂用药组方规律进行分析。方法:搜集山东中医药大学附属医院2015年1月~2016年12月小儿病毒性肺炎住院病例共134例,筛选治疗病毒性肺炎的处方共271首,应用“中医传承辅助系统(V2.5)”软件对其进行分析。结果:1.本次研究共涉及中药149味,使用频次超过54次的常用中药共计18味;2.利用关联规则分析法,得到常用药物组合16对;3.利用改进的互信息法的药物间关联度分析法,获得关联度在0.02以上的药对共69对;4.利用复杂系统熵聚类分析法,分析出可聚类成新药队的核心组合共6对,在此基础上进一步进行无监督的熵层次聚类法,挖掘出6个新候选处方。结论:治疗小儿病毒性肺炎常用治法包括宣肺化痰、疏风解表、清热解毒、通腑泻下、活血化瘀、益气健脾等;治疗小儿病毒性肺炎组方用药规律为:辨明寒热对证用药,辛宣苦降以开肺气、祛湿浊,佐以甘润培土生金,围绕“热、咳、痰、喘”四症的偏重调整配伍。
[Abstract]:Objective: to analyze the prescriptions of infantile viral pneumonia based on the software of traditional Chinese Medicine inheritance Assistance system (V2.5). Methods: 134 hospitalized children with viral pneumonia from January 2015 to December 2016 in affiliated Hospital of Shandong University of traditional Chinese Medicine were collected and 271 prescriptions for viral pneumonia were selected. The software of traditional Chinese Medicine inheritance Assistant system (V 2.5) was used to analyze it. Results: 1. The study involved 149 kinds of Chinese medicine, using more than 54 times of common Chinese medicine a total of 18; 2. By using association rule analysis, 16 pairs of commonly used drug combinations were obtained. By using the improved mutual information method, 69 pairs of drug pairs with correlation degree above 0.02 were obtained. Based on the entropy cluster analysis of complex systems, 6 pairs of core combinations of new drug teams were analyzed. On the basis of this, an unsupervised entropy hierarchical clustering method was developed, and six new prescriptions were found out. Conclusion: the common treatment methods for viral pneumonia in children include dispersing the lung and resolving phlegm, dispersing wind, clearing away heat and detoxifying, clearing the Fu organs and diarrhea, activating blood circulation and removing blood stasis, invigorating qi and invigorating spleen, etc. The prescriptions for treating viral pneumonia in children are as follows: differentiation of cold and heat against syndromes, Xin Xuan bitter lowering to open lung qi, removing dampness and turbidity, and Gran Runpei native gold, focusing on the adjustment of compatibility of "heat, cough, phlegm and asthma".
【学位授予单位】：山东中医药大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R272

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