麻杏石甘汤联合阿奇霉素对小儿支原体肺炎患者抗炎、促炎因子及免疫功能的影响

发布时间：2019-02-19 09:10

【摘要】：目的:探讨麻杏石甘汤联合阿奇霉素对小儿支原体肺炎(MPP)患者抗炎、促炎因子及免疫功能的影响。方法:选取河南中医药大学第二附属医院2014年11月—2016年4月收治的165例MPP患儿,按随机数字表法分为治疗组(83例)和对照组(82例)。对照组MPP患儿给予阿奇霉素序贯疗法进行治疗,治疗组联合麻杏石甘汤进行治疗。结果:治疗组患者总有效率为93.98%,对照组为81.71%,治疗组优于对照组(P0.05);与治疗前比较,治疗后,两组患儿血清中白细胞介素-2(IL-2)水平明显升高,且治疗组明显高于对照组(P0.05),两组患儿白细胞介素-4(IL-4),白细胞介素-10(IL~(-1)0)水平明显降低,且治疗组明显低于对照组(P0.05);与治疗前比较,治疗后两组患儿血清中白细胞介素-6(IL-6),肿瘤细胞因子-α(TNF-α)与干扰素-γ(IFN-γ)水平明显降低,且治疗组低于对照组(P0.05);与治疗前比较,治疗后,两组患儿血清中CD3+,CD4+以及红细胞C3b受体(RBC-C3bR)水平明显升高,且治疗组明显高于对照组(P0.05),CD8+与红细胞免疫复合物(RBC-ICR)水平明显降低,且治疗组明显低于对照组(P0.05);与治疗前比较,治疗后两组中医证候积分均有明显改善(P0.05),与对照组相比,治疗组中医证候积分低于对照组(P0.05),两组不良反应比较,差异无统计学意义。结论:麻杏石甘汤联合阿奇霉素治疗MPP患儿疗效显著,可能与其升高抗炎因子,降低促炎因子水平,改善患儿免疫功能有关。
[Abstract]:Objective: to investigate the effect of maxing Shigan decoction combined with azithromycin on anti-inflammatory, proinflammatory factor and immune function in children with mycoplasma pneumonia (MPP). Methods: 165 children with MPP were randomly divided into treatment group (n = 83) and control group (n = 82) from November 2014 to April 2016 in the second affiliated Hospital of Henan University of traditional Chinese Medicine. The control group (MPP) was treated with azithromycin sequential therapy, and the treatment group with Maxingshigan decoction. Results: the total effective rate was 93.98 in the treatment group and 81.71 in the control group. The treatment group was superior to the control group (P0.05). Compared with those before treatment, the serum levels of interleukin-2 (IL-2) in the two groups were significantly higher than those in the control group (P0.05). The levels of interleukin-4 (IL-4) in the two groups were significantly higher than those in the control group (P0.05). The level of interleukin-10 (IL~ (-1) 0) was significantly lower in the treatment group than in the control group (P0.05). The levels of serum interleukin-6 (IL-6), tumor cytokine 伪 (TNF- 伪) and interferon- 纬 (IFN- 纬) in the two groups were significantly lower than those in the control group (P0.05). After treatment, the levels of serum CD3, CD4 and erythrocyte C3b receptor (RBC-C3bR) in the two groups were significantly higher than those in the control group (P0.05). The level of CD8 and erythrocyte immune complex (RBC-ICR) was significantly lower in the treatment group than in the control group (P0.05). Compared with the treatment before treatment, the two groups after the treatment of TCM syndrome score improved significantly (P0.05), compared with the control group, the treatment group TCM syndrome score was lower than the control group (P0.05), the two groups of adverse reactions, the difference was not statistically significant. Conclusion: the curative effect of maxing Shigan decoction combined with azithromycin on MPP children may be related to the increase of anti-inflammatory factor, the decrease of proinflammatory factor level and the improvement of immune function in children with MPP.
【作者单位】：河南中医药大学第二附属医院;
【基金】：河南省基础与前沿技术研究计划项目(142300410070) 河南省科技攻关计划项目(0324420083) 河南中医学院科技创新团队支持计划项目(2010XCXTD11)
【分类号】：R725.6

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