合并过敏性鼻炎对儿童系统性红斑狼疮病情及治疗的影响

发布时间：2019-03-07 21:26

【摘要】：目的探讨过敏性鼻炎(AR)及其干预对儿童系统性红斑狼疮(JSLE)病情和治疗用药的影响。方法收集96例确诊的JSLE患儿临床资料,按是否合并过敏性鼻炎或其他过敏性疾病分为过敏性鼻炎组(44例)和非鼻炎过敏组(20例),以及非过敏组(32例),过敏性鼻炎组又随机分为鼻炎干预组和非干预组(各22例)。所有患儿均进行规范JSLE治疗。比较各组患儿的SLE疾病活动性指数(SLEDAI)和激素、免疫抑制剂用药情况。结果合并过敏性鼻炎组和非鼻炎过敏组的JSLE患儿治疗前的SLEDAI评分、糖皮质激素日累积剂量、免疫抑制剂用药种数均高于非过敏组(P0.05),而过敏性鼻炎组和非鼻炎过敏组间的差异无统计学意义(P0.05)。治疗1个月后,JSLE合并过敏性鼻炎患儿干预组的SLEDAI评分及激素日累积剂量低于非干预组(P0.05),两组患儿免疫抑制剂用药种数的差异无统计学意义(P0.05);治疗3个月及6个月后,干预组的SLEDAI评分、激素日累积剂量、免疫抑制剂使用种类均少于非干预组(P0.05)。结论 JSLE合并AR等过敏性疾病可能对SLE病情及治疗产生不利影响;针对AR给予干预有利于病情控制。
[Abstract]:Objective to investigate the effect of allergic rhinitis (AR) and its intervention on the condition and treatment of (JSLE) in children with systemic lupus erythematosus (SLE). Methods 96 children with JSLE were divided into allergic rhinitis group (n = 44), non-rhinitis group (n = 20) and non-allergic group (n = 32) according to whether or not they were complicated with allergic rhinitis or other allergic diseases. Allergic rhinitis group was randomly divided into two groups: rhinitis intervention group (n = 22) and non-intervention group (n = 22). All children were treated with standardized JSLE. SLE disease activity index (SLEDAI), hormone and immunosuppressive drugs were compared in each group. Results the SLEDAI score, daily cumulative dose of glucocorticoid and the number of immunosuppressants used in JSLE children with allergic rhinitis and non-rhinitis allergies before treatment were higher than those in non-allergic group (P0.05). There was no significant difference between allergic rhinitis group and non-rhinitis allergic group (P0.05). After 1 month of treatment, the SLEDAI score and the daily cumulative dose of hormone in the intervention group of JSLE with allergic rhinitis were lower than those in the non-intervention group (P0.05), and there was no significant difference in the number of immunosuppressive drugs between the two groups (P0.05). After treatment for 3 months and 6 months, the SLEDAI score, daily cumulative dose of hormone and the types of immunosuppressive agents used in the intervention group were lower than those in the non-intervention group (P0.05). Conclusion allergic diseases such as JSLE combined with AR may have adverse effects on the condition and treatment of SLE, and the intervention of AR is beneficial to the control of the disease.
【作者单位】：上海交通大学医学院附属仁济医院儿科;
【分类号】：R725.9;R765.21

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