肾病综合征激素敏感频复发患儿与支原体感染

发布时间：2019-03-19 16:22

【摘要】：目的:探讨原发性肾病综合征(NS)激素敏感频复发患儿与肺炎支原体感染的关系。方法:选取原发性肾病综合征激素敏感频复发患儿同时合并急性呼吸道感染者共35例,根据结果分肺炎支原体(MP)感染患儿为观察组,其他感染患儿为对照组,观察患儿的临床特征,对比治疗前后的各项检验指标的变化,包括24小时尿蛋白定量(24 h-Upro)、尿素氮(BUN)、血肌酐(Scr)、血浆白蛋白(Alb)、总胆固醇(Chol)等。统计分析两组患儿的治疗疗效。结果:两组治疗后各项临床生化指标均有明显改善,差异有统计学意义(P≤0.01)。治疗后24 h尿蛋白定量下降明显,从数值上看观察组较对照组下降更明显。观察组18例患儿治疗有效15例,其中完全缓解9例,部分缓解6例;对照组17例患儿治疗有效14例,其中完全缓解6例,部分缓解8例。结论:急性呼吸道感染诱发的激素敏感频复发NS患儿经过治疗后,多数能得到缓解,蛋白尿、低蛋白血症、高脂血脂、肾功能均恢复较快,预后好,其中应用阿奇霉素治疗MP感染诱发的激素敏感频复发的NS患儿疗效更显著。
[Abstract]:Objective: to investigate the relationship between (NS) hormone-sensitive relapse and Mycoplasma pneumoniae infection in children with primary nephrotic syndrome (PNS). Methods: a total of 35 children with primary nephrotic syndrome complicated with acute respiratory tract infection were selected. According to the results, children with mycoplasma pneumoniae (MP) infection were divided into observation group and control group. The clinical features of the patients were observed, and the changes of the test indexes before and after treatment were compared, including 24-hour urinary protein quantity (24 h-Upro), blood urea nitrogen (BUN), serum creatinine (Scr), plasma albumin (Alb), total cholesterol (Chol), and so on. The therapeutic effects of the two groups were analyzed statistically. Results: the clinical biochemical indexes of the two groups were obviously improved after treatment, the difference was statistically significant (P 鈮，

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