辽宁省婴幼儿血管瘤及其相关因素的Logistic回归分析

发布时间：2019-03-25 13:00

【摘要】：目的了解婴幼儿血管瘤(infantile hemangioma,IH)发生的流行病学特点,探索IH发生的可疑危险因素。方法选取363例0~2岁血管瘤患儿及332例非血管瘤患儿进行病例对照研究。对进入入选标准的患儿父母发放调查问卷,内容涵盖婴儿出生情况、父母孕前1年及孕期的生活行为方式及可能的环境危险因素等共37项,通过回归分析以了解IH的流行病学特点及发现IH发生的危险因素。结果单因素卡方、t检验和秩和检验筛选出19个P0.05的因素进行多因素Logistic回归分析,最终婴儿性别、出生体重、孕周、母亲生育年龄、胎数、产次、妊娠期高血压、孕期异常、胎盘异常、孕期使用保胎药物、反季节蔬菜水果、母亲接触化肥、父母工作中接触有害物质(P0.05)共14个因素进入Logistic回归模型,均为血管瘤发病的独立危险因素。结论除婴儿性别外,母亲生育史、父母孕期及孕前1年部分生活行为习惯包括出生体重、孕周、母亲生育年龄、胎数、产次、妊娠期高血压、孕期异常、胎盘异常、孕期使用保胎药物、反季节蔬菜水果、母亲接触化肥、父母工作中接触有害物质可能是婴幼儿血管瘤发生的高危因素。
[Abstract]:Objective to investigate the epidemiological characteristics of infantile hemangioma (infantile hemangioma,IH) and explore the suspicious risk factors of IH. Methods A case-control study was conducted in 363 cases of 2-year-old hemangioma and 332 cases of non-hemangioma. A questionnaire was issued to the parents of the children who entered the selection criteria, covering 37 items, such as the birth of the baby, the life style of the parents in the first year of pregnancy and pregnancy, and possible environmental risk factors, etc. The epidemiological characteristics of IH and the risk factors of IH were analyzed by regression analysis. Results by univariate chi-square, t-test and rank sum test, 19 factors (P0.05) were selected for multivariate Logistic regression analysis. Finally, the sex of the baby, birth weight, gestational week, maternal birth age, number of births, gestational hypertension, and so on, were analyzed. Abnormal pregnancy, abnormal placenta, pregnancy use of fetal medicine, anti-seasonal vegetable and fruit, mother exposure to fertilizer, parent exposure to harmful substances (P0.05) a total of 14 factors into the Logistic regression model. All of them were independent risk factors of hemangioma. Conclusion in addition to the sex of the baby, maternal birth history, maternal life habits during pregnancy and one year before pregnancy include birth weight, gestational week, maternal birth age, number of births, times of birth, gestational hypertension, abnormal pregnancy and abnormal placenta. Maternal exposure to chemical fertilizers and harmful substances at work may be a high risk factor for hemangioma in infants and infants with pregnancy protection drugs, anti-seasonal vegetables and fruits, and mother-to-child exposure to fertiliser.
【作者单位】：沈阳军区总医院;锦州医科大学;
【分类号】：R732.2

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