湖北省HIV感染儿童抗病毒治疗前生存时间的研究

发布时间：2019-04-01 17:50

【摘要】：目的了解湖北省艾滋病病毒(HIV)阳性儿童的流行病学特征,探讨其接受抗反转录病毒治疗(ART)前的生存时间,为儿童艾滋病的防治工作提供参考。方法自1999年1月至2015年12月,收集湖北部分地区HIV阳性儿童的相关资料并进行随访,SPSS 20.0对相关资料进行统计分析。结果 152例HIV阳性儿童中,115例(75.7%)通过母亲传播给子女,包括85例(55.9%)母婴传播(母亲产前感染HIV)及30例(19.7%)母乳传播(母亲产后输血感染HIV并对所生婴儿进行母乳喂养)。自2004年开始,新发HIV阳性儿童人数呈逐年下降趋势。未及时发现HIV阳性孕产妇,是2004年及以后HIV阳性儿童错过母婴传播阻断的主要原因。母婴、母乳、受血途径感染HIV儿童,ART前的中位生存时间分别为6.2年、11.8年、10.4年,通过母婴途径感染HIV的儿童,ART前的生存时间短于通过母乳途径、受血途径感染的儿童(P0.05)。结论应提高湖北省孕检人群HIV的检测率,尽早发现HIV阳性孕妇并予以阻断。感染时机对HIV阳性儿童ART前的疾病进程有影响。
[Abstract]:Aim to investigate the epidemiological characteristics of HIV (HIV) positive children in Hubei Province, and to explore the survival time of HIV positive children before receiving antiretroviral therapy (ARV), so as to provide reference for the prevention and treatment of HIV / AIDS in children. Methods from January 1999 to December 2015, the data of HIV positive children in some areas of Hubei Province were collected and followed up. The data were statistically analyzed by SPSS 20.0. Results of the 152 HIV positive children, 115 (75.7%) were transmitted from mother to child. There were 85 cases (55.9%) of mother-to-child transmission (HIV infection by mother) and 30 cases (19.7%) of breast-milk transmission (mother-to-child transfusion infected with HIV and breastfeeding of infants). Since 2004, the number of new HIV positive children has been decreasing year by year. The failure to detect HIV positive pregnant women in time was the main reason why HIV positive children missed mother-to-child transmission blockage in 2004 and beyond. The median pre-ART survival time was 6.2 years, 11.8 years and 10.4 years for children infected with HIV by mother-infant, breast milk and blood-infected children, respectively. The survival time before ART was shorter for children infected with HIV by mother-infant route than through breast-milk route. Children infected by blood pathway (P0.05). Conclusion the HIV detection rate of pregnant women in Hubei province should be increased, and HIV positive pregnant women should be detected as soon as possible and blocked. The timing of infection has an effect on the disease progression before ART in HIV-positive children.
【作者单位】：武汉大学中南医院感染科;昆明医科大学;襄阳市疾病预防控制中心;咸宁市疾病预防控制中心;南漳县疾病预防控制中心;浠水县疾病预防控制中心;恩施市疾病预防控制中心;
【基金】：国家自然科学基金(81000758) 湖北省自然科学基金(2010CDB06103) 武汉中青年医学骨干人才项目~~
【分类号】：R725.1

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