振幅整合脑电图在新生儿窒息早期诊断和预后评估中的临床价值

发布时间：2019-05-18 00:40

【摘要】：目的探讨振幅整合脑电图(aEEG)对新生儿窒息导致脑损伤的早期诊断及预后评估的临床价值。方法选择2015年1-9月在该院新生儿重症监护病房住院的34例足月分娩窒息新生儿(窒息组)及同期34例健康足月儿(对照组),均于生后6h内开始监测aEEG背景活动、睡眠-觉醒周期(SWC)、痫性活动(SA)的特点,并分析各指标与窒息程度、脑损伤的关系。结果窒息组新生儿脑电图呈连续者占52.9%,SWC成熟率为58.8%,均低于对照组,比较差异有统计学意义(P0.05);窒息组发生痫性活动的新生儿占11.8%,明显高于对照组,比较差异有统计学意义(P0.05)。结论新生儿出生后早期aEEG变化与围产期窒息及窒息后脑损伤密切相关,采用aEEG对出生时具有脑损伤高危因素的窒息足月新生儿提供早期诊断、早期干预的理论依据。
[Abstract]:Objective to investigate the clinical value of amplitude integrated electroencephalogram (aEEG) in early diagnosis and prognosis evaluation of brain injury caused by neonatal asphyxia. Methods from January to September 2015, 34 asphyxiated neonates with full-term delivery (asphyxia group) and 34 healthy full-term infants (control group) hospitalized in the neonatal intensive care unit of our hospital were selected to monitor the background activities of aEEG within 6 hours after birth. The characteristics of epileptic activity (SA) in sleep-arousal cycle (SWC), were analyzed, and the relationship between the indexes and the degree of asphyxia and brain injury was analyzed. Results in asphyxia group, 52.9% of neonates had continuous electroencephalogram (EEG), and the maturation rate of SWC was 58.8%, which was lower than that of the control group, and the difference was statistically significant (P 0.05). The incidence of epileptic activity in asphyxia group was 11.8%, which was significantly higher than that in control group (P 0.05). Conclusion the changes of aEEG in the early stage after birth are closely related to asphyxia and brain injury after asphyxia. AEEG is used to provide the theoretical basis for early diagnosis and early intervention of asphyxiated full-term neonates with high risk factors of brain injury at birth.
【作者单位】：第三军医大学大坪医院野战外科研究所儿科;
【基金】：国家自然科学基金资助项目(81100458)
【分类号】：R722.12

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