神经元特异性烯醇化酶表达水平与手足口病合并脑炎的Meta分析

发布时间：2019-05-30 05:48

【摘要】：目的探讨神经元特异性烯醇化酶(Neuron Specific Enolase,NSE)表达水平与手足口病(Hand-Foot-Mouth Disease,HFMD)合并脑炎的关系,为临床的预防与治疗提供更可靠依据。方法采用计算机检索中文期刊全文数据库(CNKI)、万方数据资源系统(Wanfang Database)、维普数据库(VIP)、Pub Med、EMBase、Cochrane Library等数据库从建库起到2016年7月止的文献。选用Review Manager 5.3软件和Stata 12.0软件进行Meta分析。结果最终纳入7篇文献进行Meta分析,脑炎组共448例,单纯HFMD组(普通组)共466例。脑炎组VS普通组的Meta分析显示,NSE浓度(单位:μg/l)的标准化均数差(Standardized Mean Difference,SMD)及95%可信区间(Confidence Interval,CI)分别为:血清来源(SMD=1.97,95%CI:1.75~2.19,P0.001),脑脊液来源(SMD=2.62,95%CI:2.36~2.89,P0.001)。结论本研究提示NSE浓度在HFMD合并脑炎患儿中显著升高,两者具有一定的相关性,提示检测血清NSE浓度可以判断HFMD患儿病情变化。
[Abstract]:Objective to investigate the relationship between the expression of neuron-specific enolase (Neuron Specific Enolase,NSE and hand, foot and mouth disease (Hand-Foot-Mouth Disease,HFMD) complicated with meningitis, and to provide more reliable basis for clinical prevention and treatment. Methods the Chinese periodical full-text database (CNKI), Wanfang data resource system (Wanfang Database), Vipp database (VIP), Pub Med,EMBase,Cochrane Library and other databases were searched by computer from the establishment of the database to July 2016. Review Manager 5.3 software and Stata 12.0 software were used for Meta analysis. Results Meta analysis was carried out in 7 articles. There were 448 cases in the encephalitis group and 466 cases in the simple HFMD group (common group). Meta analysis of VS in encephalitis group showed that the standardized mean difference (Standardized Mean Difference,SMD and 95% confidence interval (Confidence Interval,CI) of NSE concentration (渭 g 鈮，

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