小于胎龄儿生后早期肾脏功能初探

发布时间：2019-06-17 13:49

【摘要】：目的对小于胎龄儿(SGA)生后早期肾脏功能进行回顾性对照研究,以探寻SGA儿早期肾功能损害的诊断方法。方法选择早产SGA儿40例、足月SGA儿33例作为研究组,并以早产适于胎龄儿(AGA)80例、足月儿AGA 33例作为对照组。比较各组入院48 h内血清尿素氮(BUN)、血清肌酐(SCr)、估算肾小球滤过率(eGFR)、血压、单位体重尿量以及蛋白尿的发生情况。结果早产儿SGA组的BUN低于AGA组(P0.05),两组间SCr、eGFR、血压的差异无统计学意义(P0.05)。与足月儿AGA组比较,SGA组的SCr较高、eGFR较低,差异均有统计学意义(P0.05);两组间BUN、血压的差异无统计学意义(P0.05)。早产儿或足月儿AGA与SGA之间单位体重尿量的差异无统计学意义(P0.05)。早产儿AGA与SGA之间蛋白尿发生率的差异无统计学意义(P0.05),足月儿AGA与SGA组均无蛋白尿发生。结论 SCr、eGFR对评估SGA早期肾脏损害较为敏感。足月儿SGA较AGA肾脏功能减低。
[Abstract]:Objective to make a retrospective comparative study on early renal function in infants younger than gestational age (SGA) in order to explore the diagnostic method of early renal function damage in SGA infants. Methods 40 cases of premature SGA and 33 cases of full-term SGA were selected as the study group. 80 cases of premature (AGA) and 33 cases of full-term AGA were used as the control group. The blood pressure, urine volume per unit body weight and albuminuria were estimated by serum urea nitrogen (BUN), serum creatinine (SCr), within 48 hours after admission. Results the BUN of premature infants in SGA group was lower than that in AGA group (P 0.05). There was no significant difference in SCr,eGFR, blood pressure between the two groups (P 0.05). Compared with full-term infants AGA group, SCr in SGA group was higher and eGFR was lower, the difference was statistically significant (P 0.05), but there was no significant difference in BUN, blood pressure between the two groups (P 0.05). There was no significant difference in urine volume per unit weight between AGA and SGA in premature or full-term infants (P 0.05). There was no significant difference in the incidence of albuminuria between AGA and SGA in premature infants (P 0.05). There was no proteuria in AGA and SGA groups. Conclusion SCr,eGFR is sensitive to evaluate early renal damage in SGA. The renal function of full-term infants with SGA was lower than that of AGA.
【作者单位】：北京大学第三医院儿科;
【分类号】：R722.1

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