降钙素原检测在化脓性脑膜炎患儿中的应用研究
发布时间：2019-06-21 19:34
【摘要】：目的观察降钙素原(PCT)检测在儿童化脓性脑膜炎中的临床意义。方法选取2012年3月-2015年3月医院化脓性脑膜炎患儿29例、病毒性脑膜炎患儿45例及健康体检儿童20名,于入院当天检测三组血常规、PCT水平及化脓性脑膜炎儿童、病毒性脑膜炎儿童行脑脊液常规、生化、病原学检查和头颅影像学、脑电图检查,且于治疗后3天、5天和7天检测三组PCT水平。建立ROC曲线,明确PCT诊断儿童化脓性脑膜炎灵敏度、特异性,计算阳性预测值、阴性预测值。结果入院当天化脓性脑膜炎PCT水平高于病毒性脑膜炎、健康体检者,差异具有统计学意义(P0.05),病毒性脑膜炎与健康体检者差异无统计学意义。治疗第3、5天化脓性脑膜炎患者PCT水平分别为(3.105±2.041)ng/ml、(1.006±0.890)ng/ml高于病毒性脑膜炎患者(0.117±0.076)ng/ml、(0.115±0.082)ng/ml及健康体检者的(0.160±0.331)ng/ml、(0.160±0.331)ng/ml,差异均有统计学意义(P均0.05),第7天与病毒性脑膜炎和健康体检差异无统计学意义。脑脊液白细胞计数500×16/L与≤500×106/L者PCT水平差异无统计学意义,脑脊液蛋白升高与正常者比较、细菌培养阴性与培养阳性者比较、普通病情与重症患者比较,差异均无统计学意义。脑脊液葡萄糖含量降低患者PCT水平(3.65±0.76)ng/mL显著高于正常者(1.87±0.98)ng/ml(P0.05)。PCT≥2ng/ml及≥10.0ng/ml特异性、阳性预测值高于PCT≥0.5ng/ml。结论 PCT水平检测有助于儿童化脓性脑膜炎早期诊断、病情评估与临床指导,且能避免单一指标对中枢神经系统感染类型的误诊,效果值得肯定。
[Abstract]:Objective to observe the clinical significance of procalcitonin (PCT) detection in children with suppurative meningitis. Methods 29 children with suppurative meningitis, 45 children with viral meningitis and 20 healthy children were selected from March 2012 to March 2015. Blood routine, PCT level and purulent meningitis children were measured on the day of admission. Cerebrospinal fluid routine, biochemical, etiological examination, cephalogram and electroencephalogram (EEG) were performed in three groups of children with viral meningitis. PCT levels were measured at 3 days, 5 days and 7 days after treatment. ROC curve was established to determine the sensitivity, specificity, positive predictive value and negative predictive value of PCT in the diagnosis of suppurative meningitis in children. Results on the day of admission, the PCT level of suppurative meningitis was higher than that of viral meningitis, and the difference was statistically significant (P 0.05). There was no significant difference between viral meningitis and healthy meningitis. On the 3rd and 5th day of treatment, the level of PCT in patients with suppurative meningitis was (3.105 卤2.041) ng/ml, (1.006 卤0.890) ng/ml, which was significantly higher than that in patients with viral meningitis (0.117 卤0.076) ng/ml, (0.115 卤0.082) ng/ml and healthy controls (0.160 卤0.331) ng/ml, (0.160 卤0.331) ng/ml,. There was no significant difference between day 7 and viral meningitis and physical examination. There was no significant difference in PCT level between 500 脳 16 脳 L and 鈮，
本文编号：2504300
[Abstract]:Objective to observe the clinical significance of procalcitonin (PCT) detection in children with suppurative meningitis. Methods 29 children with suppurative meningitis, 45 children with viral meningitis and 20 healthy children were selected from March 2012 to March 2015. Blood routine, PCT level and purulent meningitis children were measured on the day of admission. Cerebrospinal fluid routine, biochemical, etiological examination, cephalogram and electroencephalogram (EEG) were performed in three groups of children with viral meningitis. PCT levels were measured at 3 days, 5 days and 7 days after treatment. ROC curve was established to determine the sensitivity, specificity, positive predictive value and negative predictive value of PCT in the diagnosis of suppurative meningitis in children. Results on the day of admission, the PCT level of suppurative meningitis was higher than that of viral meningitis, and the difference was statistically significant (P 0.05). There was no significant difference between viral meningitis and healthy meningitis. On the 3rd and 5th day of treatment, the level of PCT in patients with suppurative meningitis was (3.105 卤2.041) ng/ml, (1.006 卤0.890) ng/ml, which was significantly higher than that in patients with viral meningitis (0.117 卤0.076) ng/ml, (0.115 卤0.082) ng/ml and healthy controls (0.160 卤0.331) ng/ml, (0.160 卤0.331) ng/ml,. There was no significant difference between day 7 and viral meningitis and physical examination. There was no significant difference in PCT level between 500 脳 16 脳 L and 鈮，
本文编号：2504300
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