婴儿胆汁淤积性肝病在中国的研究现状的可视化分析

发布时间：2019-06-25 21:20

【摘要】：目的展现中国关于婴儿胆汁淤积性肝病的研究情况,描绘该领域的研究趋势,提供未来研究的可能方向。方法采用共词分析法,于2016年10月以"胆汁淤积"及"婴儿"等关键词在中国知网(CNKI)及万方数据库进行文献检索及筛选,通过Excel2010建立高频关键词共现矩阵,使用Ucinet 6.0及Netdraw绘制高频关键词可视化网络图。结果共纳入相关文献383篇。共现分析图显示,在整个国内研究领域中以"婴儿""胆汁淤积"为核心,"婴儿肝炎综合征""新生儿""肝内""胆道闭锁""遗传代谢""肝炎""巨细胞病毒""黄疸""结合胆红素"为主要研究热点,其余大部分研究集中在"肠外营养""肝胆显像""(基因)突变""肝活检"等方面,而关于疾病的外科诊断技术以及疾病的治疗的研究较少。结论中国关于婴儿胆汁淤积性肝病的研究热点集中于病因学及鉴别诊断,基因诊断是近年来的关注点,有关治疗的研究尚有待加强,新的诊断技术是未来主要的研究方向。
[Abstract]:Objective to present the research situation of cholestatic liver disease in infants in China, describe the research trend in this field, and provide the possible research direction in the future. Methods the literature was searched and screened with "cholestasis" and "baby" in (CNKI) and Wanfang database in October 2016 by co-word analysis. The co-occurrence matrix of high frequency keywords was established by Excel2010, and the visual network map of high frequency keywords was drawn by Ucinet 6.0 and Netdraw. Results A total of 383 articles were included. The co-occurrence analysis shows that in the whole domestic research field, "infant" cholestasis "is the core," infant hepatitis syndrome "," newborn "," intrahepatic "," gallbladder atresia "," genetic metabolism "," hepatitis "," cytomegalovirus "," jaundice "and" conjugated bilirubin "are the main research hotspots, while most of the other studies focus on" parenteral nutrition "," hepatobiliary imaging "(gene) mutation" liver biopsies "and so on. However, there are few studies on surgical diagnosis and treatment of diseases. Conclusion the focus of research on cholestatic liver disease in infants in China is etiology and differential diagnosis. Gene diagnosis is the focus of attention in recent years. The research on treatment needs to be strengthened, and the new diagnostic technology is the main research direction in the future.
【作者单位】：四川大学华西第二医院儿科/出生缺陷与相关妇儿疾病教育部重点实验室;
【分类号】：R725.7

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