儿童嗜酸性粒细胞性胃肠炎临床特征分析
发布时间:2021-03-01 16:51
目的:探讨儿童嗜酸性粒细胞性胃肠炎(eosinophilic gastroenteritis,EG)的临床表现、内镜、病理组织学表现及诊治情况,提高临床医生对该病的认识。对象与方法:回顾性分析2009年01月至2019年01月重庆医科大学附属儿童医院确诊EG患儿的临床资料。结果:1.一般资料:共收集到EG患儿23例,男性多于女性,男女比例为1.9:1,根据Klein’s分型方法分型,黏膜型共20例(87.0%),肌型+黏膜型共1例(4.3%),浆膜型+黏膜型共2例(8.7%)。2.临床表现:腹痛14例(60.9%)、呕吐11例(47.8%)、便血6例(26.1%)、腹泻4例(17.4%)、浮肿4例(17.4%)、腹水2例(8.7%)及呕血1例(4.3%)。3.实验室检查:11/23例外周血EOS百分比增高,12/23例轻度、中度贫血,3/22例CRP升高,11/18例隐血试验阳性,5/7例特异性IgE水平升高,3/4例过敏原斑贴试验阳性。5/6例骨髓细胞学示EOS增多,1/6例缺铁性贫血骨髓象。2例完善腹水检查,腹水涂片均可见大量EOS(94-97%)。4.内镜检查:内镜下见胃肠道充血...
【文章来源】:重庆医科大学重庆市
【文章页数】:46 页
【学位级别】:硕士
【部分图文】:
腹水涂片(瑞氏染色,×1000倍)
d) e)图 3 EG 患儿内镜下表现注:图 a)为胃底(黏膜型),可见黏膜明显充血水肿,大片白色膜状隆起,顶部红斑糜烂(箭头标注);图 b 为胃窦(黏膜型),可见黏膜充血水肿,散在大片红斑糜烂及陈旧性出血斑(箭头标注);图 c 为幽门(肌型+黏膜型),幽门肿胀,接近完全梗阻(箭头标注);图d 为十二指肠(黏膜型),黏膜充血水肿,巨大溃疡伴渗血及白苔(箭头标注);图 e 为结肠(黏膜型),黏膜见疹状红斑、红晕(箭头标注)。Figure 3 Endoscopic findings in children with EGNote: Figure a) The gastric fundus (mucosa type) : mucosa showed obvious hyperemiaand edema, accompanied by large white membranous uplift and erythematous erosion at thetop (marked by arrow). Figure b) The gastric antrum (mucosal type): hyperemia and edemawas found in the gastric antrum mucosa, accompanied by scattered large areas oferythematous erosion and old bleeding spots (marked by arrow). Figure c) The pylorus (mixed
19b)图 4 活检标本石蜡切片(HE 染色,×400 倍)a)为十二指肠黏膜组织(黏膜型),黏膜固有层大量 EOS(箭头标注/HP);图 b)为结肠黏膜组织(黏膜型),黏膜固有层大量 EOS(度 22-66 个/HP)。Figure 4 Paraffin section from biopsy specimens (HE stain,×400 timeigure a) shows the duodenal mucosal tissue (mucosal type), with a lad by arrow) infiltrating into the mucosal lamina propria (EOS densows colonic mucosal tissue (mucosal type), with large amount of EOrating into the mucosal lamina propria (EOS density 22-66 /HP).
【参考文献】:
期刊论文
[1]嗜酸性粒细胞性胃肠炎98例临床特点与诊治[J]. 许会丽,张连峰,周琳. 世界华人消化杂志. 2017(36)
[2]儿童嗜酸性粒细胞性食管炎[J]. 李东丹,徐樨巍. 中国实用儿科杂志. 2017(10)
[3]嗜酸细胞性胃肠炎合并急性胰腺炎1例并文献复习[J]. 陈先睿,黄建琪,白海涛,吴谨准. 中国循证儿科杂志. 2016(02)
[4]以“幽门梗阻、肠梗阻、腹水”为表现的嗜酸粒细胞性胃肠炎1例[J]. 王宁宁,李异玲,孙明军. 世界华人消化杂志. 2013(18)
硕士论文
[1]Eotaxin-3在EG中的表达及糖皮质激素对其表达的影响[D]. 韩莉莉.郑州大学 2016
本文编号:3057757
【文章来源】:重庆医科大学重庆市
【文章页数】:46 页
【学位级别】:硕士
【部分图文】:
腹水涂片(瑞氏染色,×1000倍)
d) e)图 3 EG 患儿内镜下表现注:图 a)为胃底(黏膜型),可见黏膜明显充血水肿,大片白色膜状隆起,顶部红斑糜烂(箭头标注);图 b 为胃窦(黏膜型),可见黏膜充血水肿,散在大片红斑糜烂及陈旧性出血斑(箭头标注);图 c 为幽门(肌型+黏膜型),幽门肿胀,接近完全梗阻(箭头标注);图d 为十二指肠(黏膜型),黏膜充血水肿,巨大溃疡伴渗血及白苔(箭头标注);图 e 为结肠(黏膜型),黏膜见疹状红斑、红晕(箭头标注)。Figure 3 Endoscopic findings in children with EGNote: Figure a) The gastric fundus (mucosa type) : mucosa showed obvious hyperemiaand edema, accompanied by large white membranous uplift and erythematous erosion at thetop (marked by arrow). Figure b) The gastric antrum (mucosal type): hyperemia and edemawas found in the gastric antrum mucosa, accompanied by scattered large areas oferythematous erosion and old bleeding spots (marked by arrow). Figure c) The pylorus (mixed
19b)图 4 活检标本石蜡切片(HE 染色,×400 倍)a)为十二指肠黏膜组织(黏膜型),黏膜固有层大量 EOS(箭头标注/HP);图 b)为结肠黏膜组织(黏膜型),黏膜固有层大量 EOS(度 22-66 个/HP)。Figure 4 Paraffin section from biopsy specimens (HE stain,×400 timeigure a) shows the duodenal mucosal tissue (mucosal type), with a lad by arrow) infiltrating into the mucosal lamina propria (EOS densows colonic mucosal tissue (mucosal type), with large amount of EOrating into the mucosal lamina propria (EOS density 22-66 /HP).
【参考文献】:
期刊论文
[1]嗜酸性粒细胞性胃肠炎98例临床特点与诊治[J]. 许会丽,张连峰,周琳. 世界华人消化杂志. 2017(36)
[2]儿童嗜酸性粒细胞性食管炎[J]. 李东丹,徐樨巍. 中国实用儿科杂志. 2017(10)
[3]嗜酸细胞性胃肠炎合并急性胰腺炎1例并文献复习[J]. 陈先睿,黄建琪,白海涛,吴谨准. 中国循证儿科杂志. 2016(02)
[4]以“幽门梗阻、肠梗阻、腹水”为表现的嗜酸粒细胞性胃肠炎1例[J]. 王宁宁,李异玲,孙明军. 世界华人消化杂志. 2013(18)
硕士论文
[1]Eotaxin-3在EG中的表达及糖皮质激素对其表达的影响[D]. 韩莉莉.郑州大学 2016
本文编号:3057757
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