不同病理特征直肠癌的MR灌注成像参数分析

发布时间：2017-12-28 16:16

本文关键词：不同病理特征直肠癌的MR灌注成像参数分析　出处：《中国医学影像技术》2016年10期 　论文类型：期刊论文

【摘要】：目的探讨不同病理特征直肠癌MR灌注成像参数的改变。方法回顾性分析经病理确诊为直肠癌的35例患者影像及病理资料,所有患者均接受MR灌注成像检查,并获得直肠癌和癌周正常直肠壁各MR灌注参数值[对比剂容积转换常数(Ktrans)、速率常数(Kep)、血管外细胞外间隙容积分数(Ve)及初始强化曲线下面积(iAUC)]。分析病理学特征,包括组织分化程度、T分期、N分期、脉管浸润和神经周围浸润情况;对不同病理状态的MR灌注参数值进行统计学分析。结果直肠癌Ktrans及iAUC均高于癌周正常直肠壁(P均0.05),直肠癌Ve低于癌周正常直肠壁(P0.05),Kep差异无统计学意义(P=0.345)。不同组织分化程度直肠癌的Ktrans、Ve、Kep和iAUC差异均无统计学意义(P均0.05)。T3~4期直肠癌Ktrans及Kep较T1~2期显著升高(P均0.05);T1~2期与T3~4期直肠癌的iAUC及Ve差异无统计学意义(P均0.05)。N1~2分期的Kep高于N0分期(P=0.006),余各灌注参数差异均无统计学意义(P均0.05)。有无脉管浸润和神经周围浸润的直肠癌MR灌注参数差异均无统计学意义(P均0.05)。结论直肠癌的MR灌注成像参数可反映其不同病理特征。
[Abstract]:Objective to investigate the changes of MR perfusion imaging parameters of rectal cancer with different pathological features. Methods a retrospective analysis of pathologically diagnosed 35 cases of patients with rectal cancer imaging and pathological data, all patients underwent MR perfusion imaging, and rectal cancer and adjacent normal rectal wall by MR perfusion parameters [contrast agent volume transfer constant (Ktrans) and rate constant (Kep), extravascular extracellular space volume fraction (Ve) and the area under the curve (iAUC)]. The pathological characteristics, including tissue differentiation, T stage, N stage, vascular invasion and perineural invasion, were analyzed. The MR perfusion parameters of different pathological status were statistically analyzed. Results Ktrans and iAUC in rectal cancer were higher than those in normal rectal wall (P = 0.05). Ve in rectal cancer was lower than that in normal rectal wall (P0.05), and there was no significant difference in Kep (P=0.345). There was no significant difference in Ktrans, Ve, Kep and iAUC between different degrees of tissue differentiation in rectal cancer (P 0.05). The Ktrans and Kep in stage T3~4 rectal cancer were significantly higher than that in T1~2 phase (P 0.05), and there was no significant difference in iAUC and Ve between T1~2 and T3~4 (P 0.05). The Kep of N1~2 staging was higher than that of N0 staging (P=0.006), and there was no significant difference in the perfusion parameters (P 0.05). There was no significant difference in MR perfusion parameters of rectal cancer with or without vascular infiltration and peripheral nerve infiltration (P 0.05). Conclusion the MR perfusion imaging parameters of rectal cancer can reflect the different pathological features.
【作者单位】：同济大学附属杨浦医院放射科;同济大学附属杨浦医院病理科;同济大学附属同济医院放射科;
【基金】：2015年度上海市杨浦区卫计委、科委青年项目(YP15Q07)
【分类号】：R735.37;R445.2
【正文快照】： 直肠癌是消化系统常见的恶性肿瘤之一,发病率呈逐年上升趋势。对于直肠癌主要采取手术治疗,全直肠系膜切除术是目前中低位直肠癌的标准手术方式[1]。近年来,抑制肿瘤血管生成已成为治疗恶性肿瘤的方法之一。研究[2]表明,在转移性结直肠癌的一线及二线治疗中,加入抗血管生成靶

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