基于血管内超声弹性成像的动脉斑块识别

发布时间：2018-01-30 12:00

本文关键词： 血管内超声弹性成像斑块识别应变成像　出处：《生物医学工程学杂志》2015年03期 　论文类型：期刊论文

【摘要】：血管内超声成像技术是冠脉检查新的"金标准",超声弹性成像技术与血管内超声成像相结合,在斑块分类和检测斑块易损程度上具有重要的应用价值。本文通过建立模拟血管分层结构的仿真模型,利用血管壁在心动周期内的收缩/舒张,得到不同血压值下的血管壁组织位移分布,从而获得组织应变。通过对不同压力间隔的血管壁弹性图进行分组对比获得了在一个心动周期内成像效果最佳的血压差组合;在最佳压力差条件下,通过仿真复合不同生物力学特性的斑块模型,验证了该方法能有效地识别不同杨氏模量的斑块特性。上述研究工作不仅具有较强的理论参考价值,在临床应用中也具有重要的指导意义和应用前景。
[Abstract]:Intravascular ultrasound imaging is a new "gold standard" for coronary artery examination. Ultrasound elastic imaging is combined with intravascular ultrasound imaging. It has important application value in plaque classification and detection of plaque vulnerability. In this paper, we establish a simulation model to simulate vascular layering structure, and utilize the contraction / relaxation of vascular wall in cardiac cycle. The displacement distribution of vascular wall was obtained under different blood pressure values. By comparing the elastic images of blood vessel wall with different pressure intervals, the best combination of blood pressure difference in a cardiac cycle was obtained. Under the optimal pressure difference condition, the plaque model with different biomechanical properties was simulated. It is verified that this method can effectively identify the plaque characteristics of different Young's modulus. The above research not only has a strong theoretical reference value, but also has important guiding significance and application prospect in clinical application.
【作者单位】：中国科学院苏州生物医学工程技术研究所;中国科学院长春光学精密机械与物理研究所;中国科学院大学;
【基金】：国家科技支撑计划资助项目(2012BAI13B02)
【分类号】：R445.1;R543
【正文快照】： 3(中国科学院大学,北京100049)引言血管内超声成像(intravascular ultrasound,IVUS)是一种目前用于评估动脉粥样斑块形态、动脉粥样硬化药物治疗和非药物性干预进程以及动脉粥样硬化易损程度的重要手段[1]。临床使用的血管内超声灰阶成像可以根据采集到的回声信号强度区别动脉

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