水合氯醛用于先天性心脏病患儿行心脏彩色多普勒超声检查时的镇静效果

发布时间：2018-01-31 18:12

本文关键词： 水合氯醛镇静先天性心脏病安全性有效性　出处：《上海医学》2015年12期 　论文类型：期刊论文

【摘要】：目的比较水合氯醛用于不同年龄、性别、先天性心脏病分型和心脏手术与否的先天性心脏病患儿行心脏彩色多普勒超声检查时镇静的有效性和安全性。方法回顾分析668例经水合氯醛50mg/kg口服镇静后进行心脏彩色多普勒超声检查的先天性心脏病患儿资料,记录患儿的一般资料、镇静用药、用药结果和不良反应,比较不同年龄(1~6个月、6~12个月、12~36个月)、性别、先天性心脏病分型(紫绀型、非紫绀型),以及有无心脏手术史的行心脏彩色多普勒超声检查时患儿镇静的有效性和安全性。结果 12~36个月患儿的镇静一次成功率显著低于年龄1~6个月、6~12个月患儿(P值均0.05),不同年龄段患儿离院时间和呼吸抑制发生率的差异均无统计学意义(P值均0.05)。非紫绀型先天性心脏病患儿镇静一次成功率显著高于紫绀型先天性心脏病患儿,离院时间显著短于紫绀型先天性心脏病患儿(P值均0.05);但非紫绀型与紫绀型患儿呼吸抑制发生率的差异无统计学意义(P0.05)。不同性别、有无心脏手术史的患儿镇静一次成功率、离院时间、呼吸抑制发生率的差异均无统计学意义(P值均0.05)。结论 50mg/kg水合氯醛口服可安全、有效地用于先天性心脏病患儿的门诊镇静,但年龄12~36个月和紫绀型先天性心脏病患儿的镇静成功率降低,但两者对呼吸抑制发生率无显著影响。性别和心脏手术与否不影响先天性心脏病患儿应用水合氯醛镇静的有效性和安全性。
[Abstract]:Objective to compare the use of chloral hydrate in different ages and sexes. The efficacy and safety of sedation in children with congenital heart disease by color Doppler echocardiography were analyzed retrospectively in 668 cases of congenital heart disease with or without cardiac surgery. Methods 668 patients with congenital heart disease underwent 50 mg / kg chloral hydrate. Data of children with congenital heart disease examined by color Doppler echocardiography after oral sedation. The general data, sedation, drug use, drug use results and adverse reactions were recorded, and the age of children was compared between 1 ~ 6 months (6 ~ 12 months), 12 ~ 36 months (n = 36), sex, congenital heart disease type (cyanosis). Acyanotic). The efficacy and safety of sedation in children with or without a history of cardiac surgery were evaluated by color Doppler echocardiography. Results the success rate of sedation in children aged 12 ~ 36 months was significantly lower than that in age 1 ~ 6 months. P value of 6 ~ 12 months was 0.05). There was no significant difference in the time of absence from hospital and the incidence of respiratory depression in different age groups (P < 0.05). The success rate of sedation in children with acyanotic congenital heart disease was significantly higher than that in children with cyanotic congenital heart disease. The time of absence from hospital was significantly shorter than that of children with cyanotic congenital heart disease (P < 0.05). However, there was no significant difference in the incidence of respiratory depression between non-cyanotic and cyanotic children (P 0.05). The success rate of sedation in children with different sex and history of cardiac surgery was not significant. Conclusion 50 mg / kg chloral hydrate is safe and effective for outpatient sedation of children with congenital heart disease. However, the success rate of sedation in children with cyanotic congenital heart disease and age of 12 ~ 36 months was lower than that in children with cyanotic congenital heart disease. Gender and cardiac surgery did not affect the efficacy and safety of chloral hydrate sedation in children with congenital heart disease.
【作者单位】：上海交通大学医学院附属上海儿童医学中心麻醉科&儿童临床药理研究室;
【基金】：上海市卫生局青年科研项目资助(20114y122)
【分类号】：R445.1;R726.1
【正文快照】： 水合氯醛的镇静效果较好、不良反应少、价格低廉,一直是小儿镇静的常用药物[1]。规范化镇静不仅要求患儿的镇静质量满足临床需要,而且关注患儿用药后的安全。水合氯醛虽然可以安全用于大多数患儿的镇静,但是先天性心脏病患儿的心、肺功能明显低于正常小儿,尤其是紫绀型先天性

【相似文献】