帕金森病睡眠障碍患者扩散张量成像

发布时间：2018-02-03 07:38

本文关键词： 帕金森病睡眠障碍扩散磁共振成像　出处：《中国医学影像技术》2015年07期 　论文类型：期刊论文

【摘要】：目的采用扩散张量成像(DTI)技术观察帕金森病睡眠障碍患者大脑微结构变化。方法对40例PDSD患者(SD组)和20例PDNSD患者(NSD组)采用帕金森病相关量表评估运动症状(MS)和非运动症状(NMS),分析DTI的FA与SD的关系。结果 SD组汉密尔顿抑郁量表(HAMD)、帕金森病非运动症状(PD-NMS)筛查问卷(NMSQ)总分较NSD组高,帕金森病睡眠量表(PDSS)总分较NSD组低,差异均有统计学意义(P均0.05);PD患者PDSS评分与HAMD、汉密尔顿焦虑量表(HAMA)、NMSQ总分呈负相关(r=-0.64、-0.63、-0.46,P均0.01);SD组FA值较NSD组降低的脑区有右侧丘脑前辐射、左侧颞中回、左侧颞下回、右侧边缘叶、右侧下丘脑及右侧杏仁核、右扣带回纤维、右内侧丘系;SD组睡眠障碍程度与右侧丘脑前辐射FA值呈负相关(r=-0.38,P=0.04)。结论 PDSD患者参与睡眠调节的大脑微结构病变明显,病变与PDSD疾病严重程度相关。可利用DTI对病情进行评估,并可能会成为早期诊断睡眠障碍PD患者的影像学标记。
[Abstract]:Objective to observe the changes of cerebral microstructures in patients with Parkinson's disease (PD) by using diffusion Zhang Liang imaging (DTI) technique. Methods 40 patients with PDSD and 20 patients with PDNSD were enrolled in this study. The motor symptoms were evaluated by Parkinson's disease related scale (NSD) and non-motor symptoms (NMSS). The relationship between FA of DTI and SD was analyzed. Results the Hamilton Depression scale (Hamd) was used in SD group. The total score of PD-NMS) was higher than that of NSD group, and the total score of Parkinson's disease sleep scale was lower than that of NSD group. The difference was statistically significant (P < 0.05). The PDSS score of PD patients was negatively correlated with the total score of HAMD and Hamilton anxiety scale (Hamilton anxiety scale) (P < 0.01). The FA value of SD group was lower than that of NSD group, including right anterior thalamic radiation, left middle temporal gyrus, left inferior temporal gyrus, right marginal lobe, right hypothalamus and right amygdaloid nucleus, right cingulate gyrus fiber, right medial colliculus system. In SD group, there was a negative correlation between the degree of sleep disturbance and the FA value of right anterior thalamus radiation. Conclusion the microstructural lesions of brain involved in sleep regulation in PDSD patients are obvious. DTI can be used to evaluate the severity of PDSD disease and may be used as an imaging marker for early diagnosis of sleep disorder PD patients.
【作者单位】：中国人民解放军第89医院神经内科;南京市浦口医院神经内科;南京医科大学附属脑科医院神经内科;
【分类号】：R742.5;R445.2
【正文快照】： 帕金森病(Parkinson disease,PD)晚期的睡眠障碍(sleep disorders,SD)早在1817年由Parkinson[1]提出。Arnulf等[2]认为,SD是PD退行性变过程中的一部分,而不是继发于PD。扩散张量成像(diffusiontensor imaging,DTI)是一种相对较新的无创成像检查方法,FA和平均弥散系数(mean dif

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