肌萎缩侧索硬化症认知损害的磁共振成像研究

发布时间：2018-02-03 16:54

本文关键词： 肌萎缩侧索硬化症认知损害静息态网络功能磁共振　出处：《北京协和医学院》2014年博士论文　论文类型：学位论文

【摘要】：肌萎缩侧索硬化症是一种累及上下运动神经元的进行性变性病,但也可出现运动系统外受累的表现,如执行功能障碍等认知受损表现。本研究应用静息态功能磁共振成像,采用低频振幅(low frequency fluctuation, ALFF)、局部一致性(regional homogeneity, ReHo)、功能连接性(functional connectivity, FC)分析方法,对3例伴有认知损害的ALS患者(ALSi组)和8例不伴认知损害的ALS患者(ALSu组)的默认网络(default mode network, DMN)、感觉运动网络(sensorimotor network,SMN)和左侧额顶网络(frontoparietal network, FPN)的功能活动性和功能连接性进行了组间比较。结果显示,与ALSu组患者相比,ALSi组患者在SMN和左侧FPN相应脑区的ALFF增加,SMN在双侧旁中央小叶与自身的FC增加,SMN的双侧旁中央小叶与左侧FPN的左额下回三角部/眶部之间FC增加,左侧FPN的左额下回三角部／眶部与DMN的左侧角回之间FC减弱。这种功能活动性及功能连接性的改变可能是左侧FPN对SMN运动功能的代偿,同时可能也是引起认知受损的原因。
[Abstract]:Amyotrophic lateral sclerosis is a progressive sexually transmitted disease involving the upper and lower motor neurons, but it can also show involvement outside the motor system. In this study, resting functional magnetic resonance imaging was performed with low-frequency amplitude low frequency fluctuation. ALFFN, regional homogeneity (ReHoA). Functional connectivity analysis method. Default network for 3 ALS patients with cognitive impairment and 8 ALS patients without cognitive impairment. Default mode network. DMNs, sensorimotor networksSMNs (sensorimotor network) and frontoparietal network (left frontopia network). The results showed that compared with the ALSu group, the ALFF in the corresponding brain region of SMN and left FPN was increased in the SMN group and the left FPN group. SMN increased between the bilateral central lobules and their own FC between the bilateral paracentral lobules and the left inferior frontal gyrus / orbital region of left FPN. FC between the left inferior frontal / orbital gyrus and the left angular gyrus of DMN was weakened in left FPN. This change of functional activity and functional connectivity may be the compensatory effect of left FPN on the motor function of SMN. It may also be the cause of cognitive impairment.
【学位授予单位】：北京协和医学院
【学位级别】：博士
【学位授予年份】：2014
【分类号】：R445.2;R746.4

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