早产儿微小型脑白质损伤的MRI-DTI评价

发布时间：2018-02-03 23:38

本文关键词： 微小型脑白质损伤弥散张量成像表观弥散系数各向异性分数早产儿　出处：《中国当代儿科杂志》2015年06期 　论文类型：期刊论文

【摘要】：目的应用磁共振弥散张量成像(DTI)对不同程度的微小型脑白质损伤(CWMD)进行评价,探讨DTI在早产儿CWMD中的应用价值。方法选取2011年11月至2012年4月住院治疗的31例早产儿,分为局灶性CWMD组11例,广泛性CWMD组10例,同时正常对照组10例,比较三组患儿侧脑室旁的表观弥散系数(ADC)值及各向异性(FA)值,应用Pearson系数检验ADC值及FA值变化的相关性,同时观察三组患儿的彩色FA图。结果局灶性CWMD组及广泛性CWMD组的ADC值均高于正常组,差异有统计学意义。局灶性CWMD组及广泛性CWMD组FA值均低于正常组,广泛性CWMD组FA值低于局灶性CWMD组,差异均有统计学意义。经过后处理的FA彩图提示侧脑室周围白质区域的FA值按正常组、局灶CWMD组及广泛CWMD组顺序依次减低。结论弥散张量成像技术可定量评估微小型CWMD程度。在CWMD评价方面,FA值比ADC值可能更加准确。
[Abstract]:Objective to evaluate the small white matter injury (CWMD) with diffusion-weighted Zhang Liang imaging (DTI). To explore the value of DTI in CWMD of premature infants. Methods 31 premature infants who were hospitalized from November 2011 to April 2012 were divided into focal CWMD group (n = 11) and focal CWMD group (n = 11). There were 10 cases of extensive CWMD group and 10 cases of normal control group. The apparent diffusion coefficient (ADCC) and anisotropy (FAA) of lateral ventricle were compared among the three groups. Pearson coefficient was used to test the correlation between ADC value and FA value. Results the values of ADC in focal CWMD group and extensive CWMD group were higher than those in normal group. FA values in focal CWMD group and extensive CWMD group were lower than those in normal group, and FA value in generalized CWMD group was lower than that in focal CWMD group. All the differences were statistically significant. The post-processed FA color map showed that the FA value of the white matter area around the lateral ventricle was normal. Conclusion Diffusion Zhang Liang imaging technique can be used to quantitatively evaluate the degree of minimal CWMD, and in the evaluation of CWMD. FA values may be more accurate than ADC values.
【作者单位】：中国医科大学附属盛京医院新生儿内科;
【分类号】：R445.2;R742
【正文快照】： 脑白质损伤(cerebral white matter damage,CWMD)是早产儿比较特异的脑损伤类型,是导致存活早产儿产生神经发育缺陷的重要原因。在美国,极低及超低出生体重儿占每年新生儿的1.5%,其中有50%通过头MRI检查发现患有不同程度的CWMD[1],存活者中5%~10%患有脑瘫,50%的患儿存在认知,

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