老年心脑血管疾病患者颈动脉斑块与血脂水平、C反应蛋白的相关性

发布时间：2018-02-05 05:30

本文关键词： 彩色多普勒超声颈动脉斑块血脂 C反应蛋白　出处：《中国老年学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨老年心脑血管疾病患者颈动脉斑块与血脂水平、C反应蛋白(CRP)的相关性。方法选择老年心脑血管疾病患者139例,经彩色多普勒超声检查证实有颈动脉斑块者79例(观察组),无颈动脉斑块者60例(对照组)。彩色多普勒超声检测粥样斑块形成情况,全自动生化分析仪测定血脂含量,酶联免疫吸附法测定CRP含量。比较两组颈动脉内膜中层厚度(IMT)、血脂、CRP水平,分析颈动脉斑块与血脂和CRP水平相关性。结果观察组IMT明显大于对照组(P0.05);低密度脂蛋白胆固醇(LDL-C)、总胆固醇(TC)和甘油三酯(TG)水平明显高于对照组,而高密度脂蛋白胆固醇(HDL-C)水平明显低于对照组(均P0.05);血清CRP水平明显高于对照组(P0.05)。观察组颈动脉斑块与LDL-C、TC、TG和CRP呈正相关,而与HDL-C呈负相关。结论老年心脑血管疾病患者颈动脉斑块与LDL-C、TC、TG和CRP呈正相关,而与HDL-C呈负相关。
[Abstract]:Objective to investigate the correlation between carotid plaque and serum lipid levels of C-reactive protein (CRP) in elderly patients with cardiovascular and cerebrovascular diseases. Methods 139 elderly patients with cardiovascular and cerebrovascular diseases were selected. There were 79 cases of carotid plaques confirmed by color Doppler ultrasonography (observation group) and 60 cases without carotid plaque (control group). Color Doppler ultrasound was used to detect the formation of atherosclerotic plaques. Blood lipid content was measured by automatic biochemical analyzer and CRP content was measured by enzyme-linked immunosorbent assay (Elisa). Results IMT in the observation group was significantly higher than that in the control group (P 0.05). The low density lipoprotein cholesterol (LDL-C), total cholesterol (TC) and triglyceride (TG) levels were significantly higher than those in the control group. The level of HDL-C in HDL-C was significantly lower than that in the control group (P 0.05). The serum CRP level was significantly higher than that in the control group (P 0.05). The carotid plaques in the observation group were positively correlated with the levels of TG and CRP. Conclusion carotid plaques in elderly patients with cardiovascular and cerebrovascular diseases were positively correlated with TG and CRP and negatively correlated with HDL-C.
【作者单位】：北京积水潭医院超声科;
【分类号】：R445.1;R54;R743
【正文快照】： 动脉粥样硬化性疾病发病率呈不断上升趋势,严重影响人们身心健康和生活质量[1,2]。脑卒中和心血管疾病的发病率和死亡率随着动脉粥样硬化程度的加重而不断上升[3]。近年研究表明血脂和C反应蛋白(CRP)等因素是动脉粥样硬化性疾病的危险因素[4,5]。本研究探讨老年心脑血管疾病患

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