卵巢肿瘤彩超血流指标与微血管密度及促血管生成素的相关性

发布时间：2018-02-09 16:08

本文关键词： 卵巢肿瘤血管生成素超声检查多普勒彩色　出处：《中国临床医学影像杂志》2015年10期 　论文类型：期刊论文

【摘要】：目的:探讨卵巢肿瘤彩超血流指标阻力指数(RI)与卵巢组织中微血管密度(MVD)及促血管生成素-2(Ang-2)的相关性。方法:经手术病理证实的55例卵巢肿瘤患者,术前应用彩色多普勒超声观察卵巢肿瘤内部血流并测定RI值,术后对所切除卵巢肿瘤组织标本分别采用免疫组化法检测其组织中MVD及Ang-2表达,分析RI与MVD、Ang-2的相关性及与肿瘤性质分级之间的相关性。结果:卵巢肿瘤的良恶性与RI呈负相关(r=-0.577,P0.05);MVD各组间呈正相关(r=0.750,P0.01);RI与MVD呈显著负相关(r=-0.537,P0.05);Ang-2与肿瘤分级呈显著正相关(r=0.573,P0.05)。结论 :RI、MVD及Ang-2分别从不同角度反映了卵巢肿瘤中新生血管的形成,Ang-2有望作为卵巢癌的临床诊断指标之一,三者联合应用可对术前术后卵巢肿瘤的血管形成进行综合评价,为卵巢癌的抗血管新生治疗及预后评估提供有价值信息,具有较重要的临床预测价值。
[Abstract]:Objective: to investigate the correlation between the resistance index of color Doppler ultrasound (RI) and microvessel density (MVD) and angiopoietin (Ang-2) in ovarian neoplasms. Methods: 55 patients with ovarian neoplasms proved by surgery and pathology were enrolled in this study. The blood flow and RI value of ovarian tumor were observed by color Doppler ultrasound before operation. The expression of MVD and Ang-2 were detected by immunohistochemical method. To analyze the correlation between RI and MVD Ang-2 and the correlation between RI and the grade of nature of tumor. Results: there was a positive correlation between RI and RI of ovarian tumor. Results: there was a positive correlation between RI and MVD in benign and malignant ovarian tumors. There was a significant positive correlation between RI and MVD. Conclusion Ang-2 and RIVD reflect angiogenesis in ovarian tumors from different angles. Ang-2 may be one of the clinical diagnostic indexes of ovarian cancer. The combination of the three methods can be used to evaluate the angiogenesis of ovarian tumor before and after operation, and to provide valuable information for anti-angiogenesis therapy and prognosis evaluation of ovarian cancer, which has important clinical predictive value.
【作者单位】：山西医学科学院山西大医院妇产科超声室;
【基金】：山西省太原市科技项目(12016906)
【分类号】：R737.31;R445.1

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