弥漫性毒性甲状腺肿患者甲状腺组织剪切波速度研究

发布时间：2018-02-09 18:48

  本文关键词： 甲状腺肿 促甲状腺素 弹性成像技术 剪切波速度 超声检查　出处：《中国全科医学》2015年18期 　论文类型：期刊论文

【摘要】：目的应用声辐射力脉冲成像(ARFI)技术探讨弥漫性毒性甲状腺肿(GD)患者甲状腺组织剪切波速度(SWV)的变化。方法选取2012年12月—2013年12月在河北医科大学第二医院确诊为GD的初发患者42例作为GD组,同时选取健康志愿者40例作为对照组。两组均取晨起空腹血检测甲状腺功能及相关抗体,ARFI均由同一医生测量甲状腺各部位的SWV,比较GD组与对照组的SWV以及与促甲状腺激素(TSH)间的相关性,并绘制受试者工作特征曲线(ROC曲线)。结果 GD组甲状腺体积大于对照组(t=12.857,P0.05)。GD组患者中23例(54.8%)血流分级为Ⅲ级,16例(38.1%)为Ⅱ级,3例(7.1%)为Ⅰ级。GD组甲状腺组织不同部位的SWV值均高于对照组(P0.05)。GD组不同部位甲状腺组织的SWV值比较,差异无统计学意义(F=1.800,P=0.312)。GD组TSH与甲状腺组织的SWV无直线相关性(r=0.254,P=0.120)。以SWV=2.1 m/s为截点时,ROC曲线下面积(AUC)最大为0.855,诊断GD的灵敏度为73.8%、特异度为90.0%、正确率为81.7%、阳性预测值为88.6%、阴性预测值为76.6%。结论 ARFI能够客观定量评估甲状腺组织的硬度,对GD的诊断与鉴别诊断有一定的临床意义。
[Abstract]:Objective to investigate the changes of shear wave velocity (SWV) in thyroid tissue of patients with diffuse toxic goiter (GDG) by means of acoustic power pulse imaging (ARFI). The first 42 cases of GD were treated as GD group. 40 healthy volunteers were selected as control group. From morning on, fasting blood samples were taken from both groups to detect thyroid function and related antibodies. SWVs in different parts of thyroid gland were measured by the same doctor. The SWV of GD group and control group were compared with that of hyperthyroidism group. The correlation between TSHs, Results the thyroid volume in GD group was larger than that in control group (12.857) P0.05. GD group (23 cases) had a blood flow grade of grade 鈪，

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