功能磁共振成像评价肝性脑病患者大脑基线活动的改变

发布时间：2018-02-10 08:05

本文关键词： 肝性脑病低频振幅扣带回磁共振成像　出处：《中国医学影像技术》2015年05期 　论文类型：期刊论文

【摘要】：目的采用fMRI技术观察肝性脑病(HE)患者大脑基线活动改变。方法对24例HE患者行静息态fMRI扫描,获取低频振幅(ALFF),其中临床症状明显的肝性脑病(OHE组)及临床症状隐匿的轻微型肝性脑病(MHE组)各12例。另选12名健康志愿者作为对照组。并进行统计学分析。结果 3组ALFF差异有统计学意义(P均0.05)的脑区主要集中于额叶、顶叶及颞叶。与对照组比较,OHE组ALFF升高的脑区包括右侧小脑后叶、左侧小脑前叶、左侧海马旁回及左侧额下回/岛叶皮质,MHE组ALFF升高的脑区包括右侧缘上回/颞上回;OHE组ALFF减低的脑区包括双侧内侧前额叶皮质、双侧后扣带回/左侧楔叶、右侧中央后回/中央前回、左侧中央旁小叶及左侧辅助运动区,MHE组ALFF减低的脑区包括左侧距状裂皮质、双侧后扣带回/右侧楔前叶、左侧中央后回、双侧中央旁小叶及双侧辅助运动区(P均0.05)。与MHE组比较,OHE组ALFF减低的脑区包括左侧前扣带回、双侧内侧前额叶皮质、双侧后扣带回、右侧角回/枕上回及右侧额中回(P均0.05)。OHE组及MHE组双侧后扣带回ALFF均与血氨水平呈负相关(P均0.05)。结论OHE及MHE患者均存在静息态下脑功能异常。
[Abstract]:The purpose of using fMRI technique to observe the hepatic encephalopathy (HE) in patients with brain baseline activity change. Methods 24 cases of HE underwent resting state fMRI scan to obtain low-frequency amplitude (ALFF), the clinical symptoms of hepatic encephalopathy (OHE group) and the clinical symptoms of occult mild hepatic encephalopathy (MHE group) with 12 cases in each other. 12 healthy volunteers as control group. Statistical analysis was carried out. Results there was significant difference in ALFF between the 3 groups (P 0.05) of the brain areas are mainly concentrated in the frontal, parietal and temporal lobes. Compared with the control group, OHE group ALFF increased in brain regions including the right posterior lobe of cerebellum, left cerebellum anterior lobe, left hippocampus gyrus and left inferior frontal gyrus / insular cortex, brain areas in MHE group increased ALFF including right supramarginal gyrus / superior temporal gyrus; brain OHE group decreased ALFF included bilateral medial prefrontal cortex, bilateral posterior cingulate / left cuneus, right postcentral gyrus and precentral gyrus, left central Paracentral lobule and left supplementary motor area, MHE group decreased ALFF brain regions including left calcarine cortex, bilateral posterior cingulate / right precuneus, left postcentral gyrus, bilateral paracentral lobule and bilateral supplementary motor area (P 0.05). Compared with MHE group, OHE group ALFF reduced brain area including the left anterior cingulate, bilateral medial prefrontal cortex, bilateral posterior cingulate gyrus, right angular gyrus / occipital gyrus and right middle frontal gyrus (P 0.05).OHE group and MHE group of bilateral posterior cingulate ALFF were negatively correlated with the level of blood ammonia was (P 0.05). Conclusion: OHE and MHE were brain function in resting state abnormalities.

【作者单位】：重庆医科大学附属第二医院放射科;
【分类号】：R575.3;R445.2

【共引文献】