高胆红素血症新生儿颅脑MRI特征与血清肝功能指标的相关性

发布时间：2018-02-11 19:40

本文关键词： 新生儿高胆红素血症磁共振肝功能指标　出处：《临床放射学杂志》2015年09期 　论文类型：期刊论文

【摘要】：目的探讨高胆红素血症新生儿颅脑6个部位的常规MRI信号强度、表观扩散系数(ADC)值与肝功能血清学指标的相关性。方法搜集临床诊断为高胆红素血症的60例新生儿治疗前的MRI资料。回顾性分析其苍白球、壳核、海马、黑质、背侧丘脑、底丘脑的T1WI信号强度、T2WI信号强度及ADC值,并与血清谷草转氨酶(AST)、血清总胆红素(TBIL)、血清间接胆红素(IBIL)对照。结果 60例高胆红素血症患儿苍白球、壳核、海马、黑质、背侧丘脑、底丘脑的T1WI信号强度均值分别为909.65±329.33、781.42±272.72、725.33±261.90、1009.67±378.04、867.81±875.50、905.43±391.74;T2WI信号强度均值分别为1247.68±116.79、1238.34±126.32、1271.32±105.33、1168.79±131.38、1242.41±124.21、1235.47±148.17;ADC均值(×10-3mm2/s)分别为1134.28±123.79、1119.49±205.57、1148.67±79.69、1040.46±108.41、1075.22±194.09、1257.77±1447.75。6个部位间2种信号强度的差异有统计学意义(F=2.297,P=0.045;F=3.733,P=0.003),ADC值的差异无统计学意义(F=0.725,P=0.605)。背侧丘脑T2WI信号强度(1242.41±124.21)与AST(61.99±35.40)呈负相关;底丘脑T1WI信号强度(905.43±391.74)与经皮肤测量颅脑额部、胸部的胆红素浓度(12.36±5.08、12.80±5.49)均呈正相关。结论 MRI指标与血清肝功能相关指标存在相关性,MRI检查有望为临床早期、无创的判断高胆红素血症对新生儿脑损伤的程度提供更多客观评价方法。
[Abstract]:Objective to investigate the conventional MRI signal intensity in 6 brain regions of neonates with hyperbilirubinemia. Methods the MRI data of 60 newborns diagnosed as hyperbilirubinemia before treatment were collected and analyzed retrospectively, including globus pallidus, putamen putamen, hippocampus, substantia nigra, dorsal thalamus. T1WI signal intensity of subthalamus and T2WI signal intensity and ADC were compared with serum glutamic oxaloacetic transaminase (AST), serum total bilirubin (TBILL) and indirect bilirubin (IBIL). Results 60 cases of hyperbilirubinemia were treated with globus pallidus, putamen putamen, hippocampus, substantia nigra, dorsal thalamus. The mean T1WI signal intensity of the subthalamus on T 1WI was 909.65 卤329.333781.42 卤272.72 725.33 卤261.90 1009.67 卤378.0447 卤867.81 卤875.50905.43 卤391.74 / T _ 2WI respectively: 1247.68 卤116.791238.34 卤126.3292.32 卤105.331168.79 卤131.31242.41 卤124.211242.41 卤124.2112447 卤148.17a ADC (脳 10-3mm ~ 2s) respectively was 1134.28 卤123.7919.49 卤205.5m-2 / s 71148.67 卤79.91040.46 卤108.48.104.104.77.74.74.74.74.77.77.77.74.77.74.77.72.77.72.72.72.42 卤124.21242.41 卤124.2128.447 卤148.77.77.72.77.72 respectively. The intensity of 1242.41 卤124.21) was negatively correlated with AST(61.99 卤35.40). The signal intensity of T1WI in the subthalamus was positively correlated with the bilirubin concentration in the frontal part of the brain and chest measured by skin. Conclusion there is a positive correlation between MRI and serum liver function. Non-invasive assessment of hyperbilirubinemia for neonatal brain injury provides more objective evaluation methods.
【作者单位】：潍坊医学院医学影像学系潍坊医学院附属医院影像中心;
【基金】：潍坊医学院附属医院青年创新基金项目(编号:K12QC1031) 潍坊市科技发展计划(政策引导类)项目(编号:201104091) 山东省自然科学基金(编号:ZR2014HL083)
【分类号】：R722.1;R445.2

【参考文献】