应用磁共振新技术在评价帕金森病治疗疗效的研究

发布时间：2018-02-15 19:51

本文关键词： 帕金森病血氧水平依赖磁共振成像灌注加权磁共振成像磁共振波谱成像磁敏感加权成像扩散张量成像　出处：《河北医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：帕金森病(Parkinson's disease,PD)是一种临床上常见的神经退行性疾病,全球大约有超过800万人罹患此病。在中国,65岁以上的人群患病率高达1700/10万,并且发病率随着年龄的增长也在不断增加。该病的主要病理改变为炓质致密部多巴胺神经元丢失及路易小体形成(Lewy body,LB)。近年来,在国内外众多专家学者的不屑努力下,我们对于PD的病理、病理生理学、临床表现、诊断技术等都有了更加深入的了解、更全面的认识。目前,对于PD治疗主要应用药物对其症状进行控制,并不能对病变进行根本性的治愈。随着科学研究的深入,涌现出许多新型的治疗PD的手段,例如:绕开血脑屏障(Blood brain barrier,BBB)治疗PD方式、突破BBB治疗PD方式以及其它的治疗手段,上述治疗方式均能在临床实验中进行并取得良好的治疗效果。治疗手段的出现促进了评价疗效体系的快速发展,由于临床上主要应用临床量表对治疗疗效进行评估,评分比较滞后于脑内微结构的改变,因此,研究者们试图应用磁共振(Magnetic resonance imaging,MRI)技术对于PD的治疗疗效进行评价,目前对于MRI技术对PD进行早期诊断的报道较多,并且随着MRI新技术的发展对于PD早期诊断更具有优势,然而应用MRI最新技术对PD治疗效果进行监测及评价的研究较少。因此,就目前PD最新治疗方式,MRI新技术对PD患者治疗效果进行评价的优势及前景做一综述。本文旨在全面搜集各种PD治疗最新技术及MRI新技术对PD治疗疗效评价的现有文献和证据,提供每种治疗方法的可靠性,并综合分析MRI新技术在评价PD患者治疗疗效过程中的作用及意义。
[Abstract]:Parkinson's disease (PD) is a common clinical neurodegenerative disease that affects more than 8 million people worldwide. In China, the prevalence rate is as high as 1700/10, 000 people over the age of 65. The main pathological changes of the disease are the loss of dopamine neurons and the formation of Lewy body LBB.In recent years, many experts and scholars at home and abroad have disdain the efforts of many experts and scholars at home and abroad, and the main pathological changes of the disease are the loss of dopamine neurons and the formation of Lewy body. We have a better understanding of the pathophysiology, pathophysiology, clinical manifestations and diagnostic techniques of PD. With the development of scientific research, there have been many new methods to treat PD, such as bypassing the blood-brain barrier blood brain barrier, breaking through the BBB treatment of PD and other treatments. The above treatment methods can be carried out in clinical experiments and obtain good therapeutic effects. The appearance of treatment methods promotes the rapid development of the evaluation system of curative effect, because the clinical scale is mainly used to evaluate the therapeutic effect. The scores lag behind the changes in the microstructures in the brain. Therefore, the researchers try to evaluate the therapeutic efficacy of PD by using magnetic resonance imaging technique, and there are more reports of early diagnosis of PD by MRI technique. With the development of new MRI technology, it is more advantageous for the early diagnosis of PD. However, there is little research on monitoring and evaluating the therapeutic effect of PD by using the latest MRI technology. This paper reviews the advantages and prospects of the latest treatment methods and new MRI techniques for the evaluation of the therapeutic effect of PD patients. This article aims to collect all kinds of existing literatures and evidences for the evaluation of the therapeutic efficacy of PD by the latest PD treatment techniques and the new MRI techniques. To provide the reliability of each treatment method, and to analyze the role and significance of new MRI technique in evaluating the therapeutic effect of PD patients.
【学位授予单位】：河北医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R742.5

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