动态增强MR定量分析对眼眶良恶性肿块的鉴别诊断价值

发布时间：2018-02-16 04:01

本文关键词： 眼眶肿块鉴别诊断磁共振成像动态增强定量分析　出处：《临床放射学杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的探讨动态增强磁共振成像(DCE-MRI)定量分析对眼眶良恶性肿块的鉴别诊断价值。方法回顾性分析经手术病理或临床随访证实的眼眶肿块64例,其中良性35例、恶性29例。DCE-MRI数据采用改良Tofts双室模型进行处理,获得定量参数:容量转运常数(K~(trans))、返流速率常数(K_(ep))和血管外细胞外间隙容积分数(V_e)。采用独立样本t检验比较良恶性组定量参数的差异,并利用受试者工作特性(ROC)曲线法分析各参数诊断眼眶恶性肿块的效能。结果眼眶恶性组K_(ep)值高于良性组(P=0.015),V_e值低于良性组(P=0.007),两组间K~(trans)值差异无统计学意义(P=0.700)。ROC曲线分析提示以V_e≤0.233诊断眼眶恶性肿块,可以获得最优的诊断效能(AUC 0.741;敏感度65.5%;特异度80.0%)。结论 DCE-MRI定量分析对眼眶良恶性肿块的鉴别诊断有一定价值,可为肿块定性诊断提供依据。
[Abstract]:Objective to investigate the dynamic enhanced magnetic resonance imaging (DCE-MRI) quantitative analysis on the differential diagnosis of orbital benign and malignant tumors. Methods a retrospective analysis of pathologically or clinically proven orbital tumor in 64 cases, 35 cases were benign, 29 cases malignant.DCE-MRI data by using the modified Tofts double chamber model was processed to obtain quantitative parameters: transport capacity constant (K~ (trans)), reflux rate constant (K_ (EP)) and extravascular extracellular space volume fraction (V_e). The differences between independent samples t test was used to compare the benign and malignant group quantitative parameters, and using the receiver operating characteristic (ROC) analysis of parameters for the diagnosis of orbital malignant tumor efficacy curve method. The results of orbital malignant group K_ (EP) value is higher than the benign group (P=0.015), the V_e value is lower than the benign group (P=0.007), K~ (trans) between the two groups was no significant difference (P=0.700).ROC curve analysis showed that V_e = 0.233 in diagnosis of orbital malignant tumors, The best diagnostic efficiency can be obtained (AUC 0.741, sensitivity 65.5%, specificity 80%). Conclusion DCE-MRI quantitative analysis is valuable for differential diagnosis of orbital benign and malignant masses, and can provide a basis for qualitative diagnosis of lumps.

【作者单位】：南京医科大学第一附属医院放射科;南京医科大学第一附属医院眼科;
【分类号】：R445.2;R739.7

【相似文献】