稳态自由进动的血氧饱和水平依赖技术在犬MR心肌评价中的应用

发布时间：2018-02-17 03:06

本文关键词： 冠状动脉疾病心肌缺血磁共振成像血氧水平依赖稳态自由进动　出处：《中国医学影像技术》2015年09期 　论文类型：期刊论文

【摘要】：目的探讨稳态自由进动(SSFP)的血氧饱和水平依赖技术(BOLD)在犬MR心肌缺血评价中的应用价值。方法采用SSFP BOLD MR成像序列对10只健康犬静息状态及腺苷负荷状态的心肌进行扫描,测ROI内的MR图像信号强度。评价图像质量,并分析信号强度与非放射性彩色微粒法测得心肌局部血流量的相关性。结果 10只犬SSFP BOLD图像质量均满足图像分析要求。静息状态及腺苷负荷状态下,犬心肌SSFP BOLD MR图像信号强度分别为126.73±32.16和109.47±23.53,差异有统计学意义(P=0.034)。静息状态和腺苷负荷状态下BOLD图像信号强度均与非放射性彩色微粒法测得的心肌局部血流量相关(r=0.67、0.72,P均0.05)。结论应用SSFP BOLD MR序列可准确测量犬心肌MR信号,有助于为犬心肌缺血无创性诊断提供参考资料。
[Abstract]:Objective to evaluate the value of steady-state free precession (SSFP) blood oxygen saturation level dependent technique (Bod) in evaluating myocardial ischemia on Mr in dogs. Methods SSFP BOLD Mr imaging sequence was used to scan the myocardium of 10 healthy dogs in resting and adenosine loading states. Measure the intensity of Mr images in ROI. Evaluate image quality. The correlation between the signal intensity and the myocardial regional blood flow was analyzed. Results the image quality of SSFP BOLD in 10 dogs met the requirements of image analysis. The signal intensities of SSFP BOLD Mr images in canine myocardium were 126.73 卤32.16 and 109.47 卤23.53, respectively, and the difference was statistically significant (P < 0.05). The intensity of BOLD images in resting and adenosine loading states was correlated with the myocardial regional blood flow measured by non-radioactive color particle method. Conclusion SSFP BOLD Mr sequence can accurately measure myocardial Mr signal in dogs. It is helpful to provide reference for non-invasive diagnosis of myocardial ischemia in dogs.
【作者单位】：第四军医大学西京医院放射科;
【基金】：国家自然科学基金青年项目(81301189;81201135)
【分类号】：R542.2;R445.2

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