DCE-MRI定量参数对前列腺癌内分泌治疗的疗效评价

发布时间：2018-02-25 07:08

本文关键词： 前列腺肿瘤扩散加权成像磁共振成像动态增强内分泌治疗　出处：《放射学实践》2017年11期 　论文类型：期刊论文

【摘要】：目的:回顾性分析前列腺癌(PCa)内分泌治疗前后DCE-MRI定量参数的变化,探讨DCE-MRI定量参数作为分析指标在用于PCa内分泌治疗后疗效监测的价值。方法:收集经病理学证实的33例PCa患者的临床和影像资料。测量定量参数:转运常数(Ktrans)、血管外细胞外间隙体积百分数(Ve)和速率常数(Kep)在内分泌治疗前后癌区的各参数值和血清PSA水平,对前后间参数变化的差异作统计学分析,并探讨DCE-MRI定量参数变化与PSA值变化之间的相关性。结果:治疗前癌区的Ktrans(3.2502±1.46)×10~(-3) min~(-1)、Kep(2.3341±1.59)×10~(-3) min~(-1)、Ve 1.1.7475±0.87、PSA(59.9054±37.15)μg/L,治疗后癌区的Ktrans(2.1873±1.19)×10~(-3) min~(-1)、Kep(1.0325±0.68)×10~(-3) min~(-1)、Ve2.0512±0.75、PSA(2.4831±3.93)μg/L;,其中癌区Ktrans、Kep值、PSA值在治疗前后间的差异均有统计学意义(P0.05),而Ve在治疗前后间的差异没有统计学意义(P0.05)。Spearman相关分析显示癌区治疗前后DCE-MRI的参数变化与PSA值变化无相关性(P0.05)。结论:DCE-MRI的定量参数Ktrans、Kep在PCa内分泌治疗后发生变化,可用于临床PCa内分泌治疗的疗效监测,可作为临床PCa疗效检测指标PSA的补充。
[Abstract]:Objective: to retrospectively analyze the changes of DCE-MRI quantitative parameters before and after endocrine therapy for prostate cancer (PCA). To explore the value of quantitative parameters of DCE-MRI as an analytical index in monitoring curative effect after endocrine therapy for PCa. Methods: clinical and imaging data of 33 patients with PCa confirmed by pathology were collected. The parameters and serum PSA levels of extracellular space volume percentage and rate constant were measured before and after endocrine therapy. Statistical analysis was made on the difference of parameters before and after, Results: before treatment, Ktrans(3.2502 卤1.46 脳 10 ~ (-3) 路min ~ (-1) Kep-1.3341 卤1.59 脳 10 ~ (-3) 脳 10 ~ (-3) 路min ~ (-1) 路min ~ (-1) V _ e = 1.1.7475 卤0.87PSA59.9054 卤37.15 渭 g / L, Ktrans(2.1873 卤1.19) 脳 10 ~ (-3) min ~ (-1) Kep-1.0325 卤0.68) 脳 10 ~ (-3) min in the cancer area before and after treatment. There was no significant difference of ve between before and after treatment. Spearman correlation analysis showed that there was no correlation between the changes of DCE-MRI parameters and PSA value before and after treatment in cancer area. Conclusion the quantitative parameter of KtransCE-Kep changes after PCa endocrine therapy. It can be used to monitor the curative effect of clinical PCa endocrine therapy and to supplement the clinical PCa therapeutic index PSA.
【作者单位】：苏州市吴中人民医院;苏州大学附属第二医院;通用电气医疗集团;
【基金】：苏州市科技局科技发展计划项目(SYS201475)
【分类号】：R445.2;R737.25

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