ADC比值鉴别诊断儿童后颅窝肿瘤

发布时间：2018-02-26 09:17

本文关键词： 表观扩散系数扩散加权成像毛细胞型星形细胞瘤髓母细胞瘤室管膜瘤　出处：《中国医学影像技术》2015年11期 　论文类型：期刊论文

【摘要】：目的探讨肿瘤与正常脑组织表观扩散系数(ADC)比值诊断儿童后颅窝肿瘤的价值。方法回顾性分析60例经手术病理证实的儿童后颅窝肿瘤,其中毛细胞型星形细胞瘤(PA)30例,髓母细胞瘤(MB)18例,室管膜瘤12例。术前均接受MR检查,包括DWI。测定肿瘤实性部分、正常脑组织ADC值,计算肿瘤与正常脑组织ADC比值。利用ROC曲线确定ADC比值对肿瘤鉴别诊断的最佳阈值。结果肿瘤与正常脑组织ADC比值PA为2.33±0.39,MB为0.96±0.19,室管膜瘤为1.52±0.26,差异有统计学意义(P均0.05)。ROC曲线分析显示区分室管膜瘤与PA的肿瘤与正常脑组织ADC比值最佳阈值为1.87,其敏感度为91.7%,特异度为86.7%;区分MB与室管膜瘤的肿瘤与正常脑组织ADC比值最佳阈值为1.19,其敏感度为88.9%,特异度为91.7%。结论肿瘤与正常脑组织ADC比值对常见儿童后颅窝肿瘤具有较高的鉴别诊断价值。
[Abstract]:Objective to evaluate the value of apparent diffusion coefficient (ADCC) ratio of tumor to normal brain in the diagnosis of posterior fossa tumor in children. Methods 60 cases of posterior cranial fossa tumor proved by operation and pathology were retrospectively analyzed, including 30 cases of hair cell astrocytoma. 18 cases of medulloblastoma and 12 cases of ependymoma were examined by Mr before operation, including DWI. The ADC of normal brain tissue was measured. The ADC ratio of tumor to normal brain tissue was calculated. The best threshold value of ADC ratio for differential diagnosis of tumor was determined by ROC curve. Results the ADC ratio of tumor to normal brain tissue was 2.33 卤0.39 MB = 0.96 卤0.19, and that of ependymoma was 1.52 卤0.26, the difference was statistically significant (P. The optimum threshold of ADC ratio between PA and ependymoma is 1.87, the sensitivity is 91.7, the specificity is 86.7, and the optimal threshold of ADC ratio between MB and ependymoma is normal brain tissue. 1.19, the sensitivity was 88.9 and the specificity was 91.7. Conclusion the ratio of tumor to normal brain tissue ADC has a higher value in differential diagnosis of common children's posterior cranial fossa tumors.
【作者单位】：重庆市大足区人民医院放射科;重庆医科大学附属第一医院放射科;
【基金】：国家临床重点专科建设项目([2013]544) 重庆市卫计委科研项目(2015ZBXM046)
【分类号】：R739.4;R445.2

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