正常及退变软骨T1弛豫值及T2弛豫值的定量研究

发布时间：2018-03-01 20:27

本文关键词： 关节软磁共振成像 T T　出处：《中国医学计算机成像杂志》2015年04期 　论文类型：期刊论文

【摘要】：目的:探讨正常及退变软骨磁共振T1驰豫值及T2弛豫值的定量研究价值。方法:采用PHILIPS Acheiva 3.0超导型磁共振仪进行T1弛豫值及T2弛豫值的定量测定,选择60例正常及退变膝关节,其中正常组(n=20)、OA(退行性骨关节炎,osteoarthritis)组(n=40);OA组按照kellgren-Lawrence评分又分为轻度OA组(n=20)、中度OA组(n=11)及重度0A组(n=9)。结果:正常组、轻度OA组、中度OA组、重度OA组平均T2驰豫值分别为(39.31±3.9)ms、(48.58±8.53)ms、(54.92±8.84)ms、(59.03±6.30)ms;采用协方差分析,协变量年龄对T2值有明显的影响(F=5.745,P=0.0180.05);四组髌软骨T2值有明显差异(F=26.579,p=0.000.05)。正常组、轻度OA组、中度OA组、重度OA组平均T1弛豫值分别为(511.70±72.25)ms、(458.03±55.89)ms、(405.89±57.30)ms、(357.92±36.74)ms。采用单因素方差分析,四组T1弛豫值有明显的差异(F=17.70,P=0.000.05)。结论:T2弛豫值、T1弛豫值随着退变程度的加重发生明显变化,其定量分析在早期OA诊断中有较高的临床应用价值。
[Abstract]:Objective: to investigate the quantitative value of T 1 relaxation and T 2 relaxation of normal and degenerated cartilage. Methods: the T 1 relaxation and T 2 relaxation of 60 normal and degenerative knee joints were measured by PHILIPS Acheiva 3.0 superconducting magnetic resonance imaging. The normal group was divided into mild OA group, moderate OA group and severe OA group according to kellgren-Lawrence score. Results: normal group, mild OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, moderate OA group, and moderate OA group. The mean T _ 2 relaxation value of severe OA group was 48.58 卤8.53 MSU 54.92 卤8.84 m ~ (-1) 59.03 卤6.30 Ms respectively. Covariance analysis showed that age of covariable had significant influence on T _ 2 value (P _ 0.0180.05), and there was significant difference in T _ 2 value of patellar cartilage in four groups. Normal group, mild OA group, moderate OA group, and moderate OA group, there were significant differences in T _ 2 value of patellar cartilage in the four groups. The normal group, mild OA group, moderate OA group, and moderate OA group, had a significant difference in T2 value, and the T _ 2 value of patellar cartilage in the four groups was significantly different. The normal group, mild OA group, moderate OA group, moderate OA group, The average T1 relaxation values of severe OA group were 458.03 卤55.89 卤55.89 卤57.30 Ms / s, 357.92 卤36.74 ms.The results showed that there was a significant difference in T1 relaxation value among the four groups (F 17.70 P0. 000.05). Conclusion the T 1 relaxation value of T 2 relaxation value and T 1 relaxation value obviously change with the degree of degeneration. The quantitative analysis has high clinical application value in early diagnosis of OA.
【作者单位】：上海交通大学附属第六人民医院放射科;
【基金】：国家自然科学基金No.81171312~~
【分类号】：R445.2;R681.3

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