带状疱疹后遗神经痛患者脑基础活动改变的功能核磁共振研究

发布时间：2018-03-04 12:15

本文选题：带状疱疹后遗神经痛　切入点：功能核磁共振成像　出处：《生物化学与生物物理进展》2015年10期 　论文类型：期刊论文

【摘要】：带状疱疹后遗神经痛(postherpetic neuralgia,PHN)是临床上一种慢性顽固性神经病理性疼痛,然而,对于其潜在的中枢机制还知之甚少.为了进一步探讨带状疱疹后遗神经痛患者的相关脑区活动,利用功能核磁共振成像低频振幅振荡(ALFF)技术观察带状疱疹后遗神经痛患者的基础脑区活动.8名带状疱疹后遗神经痛患者与8名性别、年龄相匹配的健康者行静息态功能磁共振(f MRI)成像扫描,用SPM8中的多重回归分析,在控制被试年龄、性别、教育年限的影响下,将每个体素的ALFF值同每个被试的病程、视觉模拟评分(visual analog scale,VAS)进行相关分析.与健康志愿者相比,PHN组与VAS评分相关的ALFF值增高的脑区有:右侧小脑后叶、前额叶背外侧区域(BA11/46/47)、右侧顶叶(BA40)、右侧舌回(BA17/18/19);与VAS评分相关的ALFF值降低的脑区有:右侧颞中回(BA21)、左侧舌回(BA17/18)、右侧小脑前叶、左侧后扣带回(BA30/19)和右侧中央前回(BA3/4/6);PHN组与病程相关的ALFF值增高的脑区有:右侧小脑后叶、前额叶背外侧区域(BA9/10/11/47)、左侧颞上回(BA38)、右侧顶叶和右侧舌回(BA17/18/19);与病程相关ALFF值降低的脑区有:左侧海马旁回(BA28)、右侧小脑前叶、左侧扣带回(BA24)、右侧颞上回(BA13)、左侧中央前回和右侧顶下小叶(BA39/40).研究结果提示,涉及疼痛的情绪、警觉行为、注意的脑区在带状疱疹后遗痛慢性疼痛的产生和维持中发挥重要作用.
[Abstract]:Postherpetic neuralgia (PHN) is a chronic intractable neuropathic pain. However, little is known about its underlying central mechanism. Low frequency amplitude oscillations of functional magnetic resonance imaging (FNMR) technique were used to observe the activity of basal brain area in 8 patients with postherpetic neuralgia and 8 patients with postherpetic neuralgia. The age-matched healthy subjects were scanned with resting functional magnetic resonance imaging (MRI). The ALFF value of each voxel was compared with the course of each subject under the influence of age, sex and years of education under the influence of multiple regression analysis in SPM8. Visual analogue score (VAS) was used to analyze the correlation between VAS score and ALFF in the right cerebellar posterior lobe, as compared with the healthy volunteers, the right cerebellum posterior lobe, the right cerebellar posterior lobe, and the right cerebellar posterior lobe. In the dorsolateral prefrontal lobe, BA11 / 46 / 47, in the right parietal lobe, in the right parietal lobe, in the right lingual gyrus, in the 17 / 18 / 19 of the right lingual gyrus BA17 / 18, in the right middle temporal gyrus, in the right middle temporal gyrus BA21, in the left lingual gyrus 17 / 18, in the right anterior cerebellar lobe, in the right cerebellum. In the left posterior cingulate gyrus (BA30 / 19) and the right precentral gyrus (BA3 / 4 / 6), the pathogenesis-related ALFF increased in the right posterior cerebellar lobe. The right parietal lobe and right lingual gyrus in the right parietal lobe and the right lingual gyrus had 17 / 18 / 19 of a total of BA9 / 10 / 11 / 47, respectively. The regions with reduced ALFF related to the course of the disease were: left paracarpal gyrus BA28, right anterior cerebellar lobe. Left cingulate gyrus, right superior temporal gyrus, right superior temporal gyrus, left precentral gyrus and right inferior parietal lobules, BA39 / 40. The results suggest that the brain regions involved in pain, alertness, and attention play an important role in the generation and maintenance of chronic pain after herpes zoster.
【作者单位】：深圳大学南山医院疼痛科;北京师范大学认知神经科学与学习国家重点实验室;首都医科大学宣武医院北京功能神经外科研究所;福建医科大学附属第一医院影像科;杭州师范大学认知与脑疾病研究中心;
【基金】：中国博士后基金(20100470218) 广东省医学科研基金(A2012596)资助项目~~
【分类号】：R445.2;R752.12

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