扩散张量成像评价多系统萎缩患者幕下纤维束

发布时间：2018-03-06 17:46

本文选题：多系统萎缩　切入点：扩散磁共振成像　出处：《中国医学影像技术》2015年09期 　论文类型：期刊论文

【摘要】：目的探讨MR DTI参数对多系统萎缩(MSA)患者幕下区域病变的诊断价值。方法对8例临床诊断为MSA患者(MSA组)和10名正常人(对照组)分别行常规头MR和DTI扫描。测量双侧小脑中脚(MCP)宽度、脑桥前后径以及双侧小脑下脚(ICP)、小脑中脚(MCP)、小脑上脚(SCP)、脑干皮质脊髓束(CST)、交叉纤维(CF)、内侧丘系(ML)及小脑白质的ADC和FA值,并进行统计学分析。结果 MSA组双侧ICP、双侧MCP、双侧SCP、右侧ML及双侧小脑白质的FA值显著低于对照组;MSA组右侧ICP、双侧MCP、双侧SCP、CF、左侧ML及双侧小脑白质的ADC值显著高于对照组。MCP的ADC值、FA值与其萎缩程度有相关性;CST、CF、ML的ADC、FA值与脑桥萎缩程度有相关性。对照组、MSA组"十字征"阴性患者、阳性患者间ADC值、FA值差异有统计学意义。结论 DTI可活体无创评价MSA幕下区域脑组织病变,较常规MRI更敏感地发现结构异常。
[Abstract]:Objective to evaluate the value of Mr DTI parameters in the diagnosis of subtentorial regional lesions in patients with multisystem atrophy. Methods conventional head Mr and DTI scanning were performed in 8 patients with MSA and 10 normal subjects (control group). The width of MCPs in bilateral cerebellum, The ADC and FA values of the anterior and posterior pons, the bilateral inferior cerebellar peduncle, the middle cerebellar pedunculum, the superior cerebellar peduncle, the corticospinal tract of the brain stem and the spinal tract of the brain stem, the crossed fibers, the medial colliculus, and the white matter of the cerebellum. Results the FA values of bilateral ICP, bilateral MCP, bilateral SCP, right ML and bilateral cerebellar white matter in MSA group were significantly lower than those in control group. The ADC values of bilateral ADC, left ML and bilateral cerebellar white matter were significantly higher than those in control group. There was a correlation between the ADC value of MCP and the degree of atrophy in the control group, and there was a correlation between the value of ADC and the degree of pons atrophy in the control group, while in the control group, the "cross sign" was negative in the control group. Conclusion DTI can be used to evaluate the pathological changes of the subtentorial area of MSA in vivo and to detect structural abnormalities more sensitively than conventional MRI.
【作者单位】：中国医科大学附属第一医院放射科;中国医科大学附属第一医院神经内科;
【分类号】：R742;R445.2

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