超声诊断胎儿侧脑室扩张合并畸形及其与染色体异常的关系

发布时间：2018-03-07 13:53

本文选题：侧脑室　切入点：扩张　出处：《中国医学影像学杂志》2017年08期 　论文类型：期刊论文

【摘要】：目的探讨胎儿侧脑室扩张合并畸形及其与染色体异常的关系,为临床咨询提供参考。资料与方法回顾性分析150例经超声诊断为侧脑室扩张胎儿的超声图像、染色体核型分析及高分辨微阵列比较基因组杂交技术(aCGH)结果。结果150例侧脑室扩张胎儿中,孤立性侧脑室扩张81例,合并胎儿超声软指标30例,合并其他中枢神经系统畸形22例,合并其他畸形17例。以上4组染色体核型分析中,异常核型13例,a CGH异常15例。各组染色体异常及aCGH检出率差异有统计学意义(P0.05),其中超声软指标组染色体及aCGH异常率显著高于单纯性侧脑室扩张组(P0.05),其余各组两两比较差异均无统计学意义(P0.05)。结论产前超声发现侧脑室扩张应仔细检查胎儿各系统。合并胎儿超声软指标或其他结构畸形时,染色体异常的几率明显增加;孤立性侧脑室扩张也需排除染色体异常并定期超声随访。
[Abstract]:Objective to explore the relationship between fetal lateral ventricular dilatation and malformation and its relationship with chromosomal abnormalities, and to provide reference for clinical consultation. Materials and methods Ultrasound images of 150 cases of fetus with lateral ventricular dilatation diagnosed by ultrasound were analyzed retrospectively. Results among 150 cases of lateral ventricular dilatation, 81 cases were isolated lateral ventricular dilatation, 30 cases were complicated with soft index of fetal ultrasound. There were 22 cases with other central nervous system malformations and 17 cases with other malformations. There were significant differences in chromosome abnormality and aCGH detection rate among 13 cases with abnormal karyotype and 15 cases with abnormal karyotype. The abnormal rate of chromosome and aCGH in soft index group was significantly higher than that in simple lateral ventricular dilatation group (P0.05). Conclusion the fetal systems should be carefully examined in prenatal ultrasound for detecting lateral ventricular dilatation. Chromosomal abnormalities were significantly increased, and solitary lateral ventricular dilatation was also necessary to exclude chromosomal abnormalities and to follow up regularly with ultrasound.
【作者单位】：广东省妇幼保健院超声诊断科;
【基金】：广东省科技厅计划项目(2016ZC0187)
【分类号】：R445.1;R714.5

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